Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.838

The method score is based on:

Property Details
Experiments 11782427, 34941261
Identification Methods affinity chromatography technology, enzymatic study, in-gel kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PH, PH~Pkinase
Common GO terms GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
and 2 others

more...

Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 480
Hs

1 676
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024