HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: EXO1 (Q9UQ84)
Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI)
Gene: EXO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.50	0.660

Property	Details
Experiments	21533173, 35271311, 36931259, 22222486, 24255178
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 846
+	Hs
		910169 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		EXO1_HUMAN (1-846): 0: 1208: 100.00
+	Hs
		927667 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		EXO1_HUMAN (1-846): 0: 1208: 100.00
+	Hs
		647387 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		EXO1_HUMAN (1-846): 0: 1208: 100.00
+	Hs
		905269 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		EXO1_HUMAN (1-846): 0: 1208: 100.00
+	Hs
		982630 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		EXO1_HUMAN (1-846): 0: 1208: 100.00
+	Hs
		684402 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		EXO1_HUMAN (1-846): 0: 1208: 100.00
+	Hs
		764357 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		FEN1_HUMAN (1-365): 6e-128: 390: 25.93
+	Hs
		904621 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		GEN_HUMAN (1-338): 5.74e-91: 309: 16.77
+	Hs
		982056 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		GEN_HUMAN (1-338): 5.74e-91: 309: 16.77
+	At
		965323 14332_ARATH (1-241): 4.75e-145: 407: 63.27		UVH3_ARATH (1-109): 3.08e-32: 137: 23.85