HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 530
+	Hs
		909878 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369071 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		927369 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369315 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369354 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		647162 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		377131 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		683595 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		904942 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369023 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Mm
		509305 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		369070 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369308 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		320172 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Mm
		509343 1433B_MOUSE (1-239): 3.73e-99: 290: 68.62		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		377266 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Mm
		509296 1433G_MOUSE (1-242): 1.86e-98: 289: 65.16		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		487313 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487149 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		437636 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		MCR_HUMAN (141-408): 5.92e-38: 150: 34.03