HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	15778465
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 903
+	Hs
		125183 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		647191 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125318 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		684276 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		125351 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Mm
		910302 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NED4L_MOUSE (2-900): 0: 765: 32.32
+	Hs
		909930 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		927423 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		125169 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		683894 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808077 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Mm
		93259 1433S_MOUSE (1-248): 4.84e-154: 429: 97.58		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Mm
		93264 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Hs
		808081 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		646713 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		909745 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	At
		788566 14333_ARATH (3-247): 2.63e-144: 405: 58.30		UPL2_ARATH (489-901): 3.99e-156: 510: 39.81
+	Hs
		927228 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Rn
		910358 1433E_RAT (2-246): 4.41e-146: 410: 60.41		NEDD4_RAT (7-426): 3.03e-54: 205: 18.07
+	Mm
		808343 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38