HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	34294877, 15778465, 36931259
Identification Methods	unspecified method, affinity chromatography technology, proximity labelling technology, cross-linking study, tandem affinity purification
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 975
+	Hs
		909930 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Mm
		910302 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NED4L_MOUSE (17-975): 0: 1014: 98.02
+	Hs
		927423 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Mm
		93259 1433S_MOUSE (1-248): 4.84e-154: 429: 97.58		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Mm
		93264 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Hs
		684266 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Mm
		808343 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Hs
		683894 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125183 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		808077 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125318 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		808081 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125351 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		647191 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		646713 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125169 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		909745 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		927228 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	At
		788566 14333_ARATH (3-247): 2.63e-144: 405: 58.30		UPL2_ARATH (556-972): 1.55e-158: 520: 39.16
+	Rn
		910358 1433E_RAT (2-246): 4.41e-146: 410: 60.41		NEDD4_RAT (13-452): 2.05e-63: 233: 46.82