HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: M3K20 (Q9NYL2)
Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein kinase kinase kinase MLT) (Mixed lineage kinase 7) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Sterile alpha motif- and leucine zipper-containing kinase AZK)
Gene: MAP3K20

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	15778465, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 800
+	Hs
		910094 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K20_HUMAN (1-800): 0: 1246: 100.00
+	Hs
		683959 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K9_HUMAN (7-326): 7.7e-116: 378: 38.91
+	Hs
		683977 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	At
		965327 14332_ARATH (3-248): 2.23e-144: 405: 58.47		PBS1_ARATH (2-359): 2.99e-132: 403: 19.07
+	At
		1277300 14337_ARATH (2-247): 4.35e-147: 413: 58.07		SERK1_ARATH (1-305): 6.82e-126: 392: 19.94
+	Hs
		684098 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		M3K21_HUMAN (9-326): 1.09e-109: 360: 36.70
+	At
		965320 14332_ARATH (3-248): 2.23e-144: 405: 58.47		BAK1_ARATH (1-262): 4.62e-126: 392: 21.84
+	Hs
		683884 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		909438 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K9_HUMAN (7-326): 7.7e-116: 378: 38.91
+	Hs
		909462 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	Hs
		337367 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85
+	Hs
		909655 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		M3K21_HUMAN (9-326): 1.09e-109: 360: 36.70
+	Hs
		926918 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		M3K9_HUMAN (7-326): 7.7e-116: 378: 38.91
+	Hs
		789053 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		926946 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		M3K10_HUMAN (10-326): 2.28e-116: 376: 38.66
+	Hs
		927089 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		M3K11_HUMAN (12-331): 1.29e-112: 364: 37.01
+	Hs
		337416 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85
+	Hs
		927141 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		M3K21_HUMAN (9-326): 1.09e-109: 360: 36.70
+	Hs
		789056 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ABL2_HUMAN (9-338): 3.12e-105: 351: 30.50
+	Hs
		337420 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		ABL1_HUMAN (3-343): 1.65e-99: 335: 26.85