HitPredict

Interactor 1: FCG2C (P31995)
Low affinity immunoglobulin gamma Fc region receptor II-c (IgG Fc receptor II-c) (CDw32) (Fc-gamma RII-c) (Fc-gamma-RIIc) (FcRII-c) (CD antigen CD32)
Gene: FCGR2C

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Hs			1 304
+	Hs
		580946 FCG2C_HUMAN (1-323): 2.58e-76: 238: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		685214 FCG2C_HUMAN (1-323): 2.58e-76: 238: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		557622 FCG2C_HUMAN (1-323): 2.58e-76: 238: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		519376 FCG2A_HUMAN (38-323): 1.1e-60: 198: 91.70		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		685203 FCG2B_HUMAN (135-321): 3.73e-13: 71: 14.36		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		580919 CD22_HUMAN (40-242): 3.64e-43: 160: 22.75		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		590607 CD22_HUMAN (40-242): 3.64e-43: 160: 22.75		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		519329 FCGR1_HUMAN (133-313): 1.19e-10: 63.7: 14.92		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		557632 DCC_HUMAN (26-323): 4.23e-45: 166: 11.52		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Mm
		722902 CD22_MOUSE (3-275): 6.66e-17: 83.4: 16.09		PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43
+	Mm
		722901 CD22_MOUSE (3-275): 6.66e-17: 83.4: 16.09		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		580945 FCG2B_HUMAN (135-321): 3.73e-13: 71: 14.36		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		855816 TITIN_HUMAN (5-321): 3.05e-09: 60.6: 10.63		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		209143 FCRL2_HUMAN (28-299): 1.48e-26: 111: 17.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		685205 FCG2B_HUMAN (135-321): 3.73e-13: 71: 14.36		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924597 MYLK_HUMAN (236-313): 1.1e-09: 61.7: 11.11		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924478 PGBM_HUMAN (127-319): 1.54e-09: 61.4: 17.70		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Ce
		136804 UNC89_CAEEL (235-323): 5.3e-10: 62.9: 6.93		VAV_CAEEL (13-194): 4.87e-22: 98.4: 23.94
+	Hs
		557621 FCG2B_HUMAN (135-321): 3.73e-13: 71: 14.36		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		557704 MYLK_HUMAN (236-313): 1.1e-09: 61.7: 11.11		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00