HitPredict

Interactor 1: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Interactor 2: APJ (P35414)
Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)
Gene: APLNR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	30409826
Identification Methods	split luciferase complementation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane GO:0060326 - cell chemotaxis
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 409 Hs			1 380
+	Rn
		663954 ARRB2_RAT (1-409): 0: 682: 95.85		Q8VBU7_RAT (1-376): 1.71e-73: 236: 19.85
+	Hs
		428933 ARRB2_HUMAN (1-409): 0: 688: 100.00		ADRB2_HUMAN (1-349): 2e-70: 228: 20.47
+	Hs
		674827 ARRB2_HUMAN (1-409): 0: 688: 100.00		AGTR1_HUMAN (24-349): 4.62e-65: 212: 31.80
+	Rn
		626614 ARRB2_RAT (1-409): 0: 682: 95.85		AGTRA_RAT (1-366): 4.52e-66: 215: 28.34
+	Hs
		685822 ARRB2_HUMAN (1-409): 0: 688: 100.00		OPRD_HUMAN (23-362): 1.55e-63: 209: 26.69
+	Hs
		827128 ARRB1_HUMAN (1-407): 0: 661: 76.15		CCR5_HUMAN (9-353): 1.81e-74: 236: 25.49
+	Hs
		827197 ARRB1_HUMAN (1-407): 0: 661: 76.15		MTR1L_HUMAN (1-376): 2.74e-66: 222: 17.20
+	Hs
		674834 ARRB1_HUMAN (1-407): 0: 661: 76.15		AGTR1_HUMAN (24-349): 4.62e-65: 212: 31.80
+	Hs
		781016 ARRB1_HUMAN (1-407): 0: 661: 76.15		OPRD_HUMAN (23-362): 1.55e-63: 209: 26.69
+	Rn
		626613 ARRB1_RAT (1-399): 0: 654: 76.90		AGTRA_RAT (1-366): 4.52e-66: 215: 28.34
+	Mm
		669680 ARRB1_MOUSE (1-399): 0: 652: 76.90		AGTRA_MOUSE (1-366): 2.56e-66: 215: 28.34
+	Hs
		685848 ARRB2_HUMAN (1-409): 0: 688: 100.00		AGTR2_HUMAN (31-345): 2.4e-34: 132: 30.72
+	Hs
		626815 ARRB1_HUMAN (1-407): 0: 661: 76.15		ACKR3_HUMAN (34-317): 1.58e-36: 137: 29.27