HitPredict

Interactor 1: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Interactor 2: MP2K4 (P45985)
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)
Gene: MAP2K4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	11090355, 19782076
Identification Methods	affinity chromatography technology, unspecified method, peptide array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005634 - nucleus GO:0005829 - cytosol GO:0060090 - molecular adaptor activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 409 Hs			1 399
+	Hs
		682136 ARRB2_HUMAN (1-409): 0: 688: 100.00		AKT2_HUMAN (57-399): 3.9e-126: 374: 20.86
+	Hs
		681683 ARRB2_HUMAN (1-409): 0: 688: 100.00		AKT1_HUMAN (74-399): 9.1e-126: 373: 19.22
+	Mm
		682122 ARRB2_MOUSE (1-409): 0: 682: 96.34		AKT1_MOUSE (74-399): 4.17e-126: 374: 19.22
+	Hs
		800970 ARRB1_HUMAN (1-407): 0: 661: 76.15		MP2K4_HUMAN (24-399): 1.3e-133: 390: 100.00
+	Hs
		681739 ARRB1_HUMAN (1-407): 0: 661: 76.15		AKT1_HUMAN (74-399): 9.1e-126: 373: 19.22
+	Mm
		682118 ARRB1_MOUSE (1-399): 0: 652: 76.90		AKT1_MOUSE (74-399): 4.17e-126: 374: 19.22
+	Hs
		805363 ARRB1_HUMAN (1-407): 0: 661: 76.15		MP2K3_HUMAN (22-387): 5.5e-121: 356: 46.72
+	Dm
		1097532 Q9V393_DROME (3-402): 0: 594: 57.48		DSOR1_DROME (54-394): 4.56e-99: 302: 37.43
+	Hs
		685915 ARRB2_HUMAN (1-409): 0: 688: 100.00		MP2K1_HUMAN (100-393): 1.72e-60: 202: 36.20
+	Hs
		153095 ARRC_HUMAN (7-393): 0: 534: 53.79		MP2K7_HUMAN (48-394): 7.51e-113: 338: 45.87