HitPredict

Interactor 1: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Interactor 2: PE2R2 (P43116)
Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor)
Gene: PTGER2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	11418617, 24069330
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 409 Hs			1 358
+	Hs
		685812 ARRB2_HUMAN (1-409): 0: 688: 100.00		PE2R4_HUMAN (22-354): 2.36e-71: 231: 30.79
+	Hs
		428933 ARRB2_HUMAN (1-409): 0: 688: 100.00		ADRB2_HUMAN (3-356): 6.02e-65: 213: 16.85
+	Rn
		663954 ARRB2_RAT (1-409): 0: 682: 95.85		Q8VBU7_RAT (3-352): 1.47e-65: 214: 16.76
+	Hs
		723237 ARRB1_HUMAN (1-407): 0: 661: 76.15		PE2R4_HUMAN (22-354): 2.36e-71: 231: 30.79
+	Hs
		441648 ARRB2_HUMAN (1-409): 0: 688: 100.00		ADRB1_HUMAN (7-351): 5.08e-58: 196: 15.58
+	Hs
		656989 ARRB2_HUMAN (1-409): 0: 688: 100.00		5HT2A_HUMAN (10-333): 3.02e-55: 189: 14.25
+	Hs
		685813 ARRB2_HUMAN (1-409): 0: 688: 100.00		APJ_HUMAN (6-356): 1.49e-55: 187: 15.99
+	Hs
		685822 ARRB2_HUMAN (1-409): 0: 688: 100.00		OPRD_HUMAN (2-357): 5.56e-55: 186: 12.98
+	Hs
		600867 ARRB2_HUMAN (1-409): 0: 688: 100.00		TA2R_HUMAN (2-347): 5.01e-55: 185: 27.37
+	Hs
		435863 ARRB2_HUMAN (1-409): 0: 688: 100.00		OPSD_HUMAN (30-352): 3.16e-53: 181: 14.72
+	Hs
		441649 ARRB1_HUMAN (1-407): 0: 661: 76.15		ADRB1_HUMAN (7-351): 5.08e-58: 196: 15.58
+	Hs
		781016 ARRB1_HUMAN (1-407): 0: 661: 76.15		OPRD_HUMAN (2-357): 5.56e-55: 186: 12.98
+	Hs
		793171 ARRB1_HUMAN (1-407): 0: 661: 76.15		PE2R2_HUMAN (1-358): 3.7e-55: 186: 100.00
+	Bt
		362126 ARRS_BOVIN (5-405): 0: 553: 51.46		OPSD_BOVIN (30-352): 3.03e-61: 201: 15.64
+	Hs
		435859 ARRS_HUMAN (4-407): 0: 541: 51.91		OPSD_HUMAN (30-352): 3.16e-53: 181: 14.72
+	Hs
		435866 ARRC_HUMAN (7-393): 0: 534: 53.79		OPSD_HUMAN (30-352): 3.16e-53: 181: 14.72