HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.964

Property	Details
Experiments	26186194, 28514442, 33961781, 38334954, 39422127, 35575683, 20618440, 21827211
Identification Methods	affinity chromatography technology, cross-linking study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~14-3-3
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0008104 - intracellular protein localization and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 248
+	Hs
		730483 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		1433S_HUMAN (1-248): 3.5e-158: 440: 100.00
+	Hs
		971385 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		1433E_HUMAN (2-246): 4.43e-146: 410: 60.41
+	At
		1030842 14332_ARATH (3-243): 8.69e-144: 404: 61.22		14332_ARATH (3-248): 2.24e-144: 405: 58.47
+	At
		840204 14332_ARATH (3-243): 8.69e-144: 404: 61.22		14331_ARATH (3-241): 4.52e-144: 405: 56.85
+	At
		840380 14332_ARATH (3-243): 8.69e-144: 404: 61.22		14333_ARATH (3-247): 2.64e-144: 405: 58.30
+	At
		1030875 14332_ARATH (3-243): 8.69e-144: 404: 61.22		14339_ARATH (2-244): 1.17e-142: 401: 55.56
+	At
		854982 14332_ARATH (3-243): 8.69e-144: 404: 61.22		14334_ARATH (3-248): 1.24e-142: 401: 56.45
+	Hs
		971391 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		1433Z_HUMAN (1-242): 8.34e-142: 398: 70.66
+	Sl
		1020571 14336_SOLLC (3-243): 1.31e-142: 401: 61.79		14337_SOLLC (2-244): 9.96e-142: 398: 56.38
+	At
		840554 14332_ARATH (3-243): 8.69e-144: 404: 61.22		14335_ARATH (2-247): 4.56e-140: 395: 56.05
+	At
		1030907 14332_ARATH (3-243): 8.69e-144: 404: 61.22		14311_ARATH (2-244): 2.97e-138: 390: 57.20
+	At
		871206 14332_ARATH (3-243): 8.69e-144: 404: 61.22		14310_ARATH (2-247): 2.91e-137: 387: 53.63
+	Mm
		972199 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		1433Z_MOUSE (1-243): 1.35e-136: 385: 69.96
+	Hs
		690882 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		1433T_HUMAN (1-238): 1e-107: 312: 71.85
+	Hs
		729728 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		1433B_HUMAN (1-239): 3.42e-100: 293: 68.62
+	Mm
		972307 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		1433B_MOUSE (1-239): 3.75e-99: 290: 68.62
+	Hs
		966172 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		1433G_HUMAN (1-242): 1.87e-98: 289: 65.16
+	Mm
		967093 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		1433G_MOUSE (1-242): 1.87e-98: 289: 65.16
+	Mm
		972201 1433E_MOUSE (2-243): 1.32e-144: 406: 63.53		1433F_MOUSE (2-242): 1.73e-96: 284: 64.20
+	Hs
		971429 1433E_HUMAN (2-243): 1.32e-144: 406: 63.53		1433F_HUMAN (2-242): 2.79e-96: 283: 64.20