HitPredict

Interactor 1: HOG1 (P32485)
Mitogen-activated protein kinase HOG1 (MAP kinase HOG1) (EC 2.7.11.24) (High osmolarity glycerol response protein 1)
Gene: HOG1

Interactor 2: SMP1 (P38128)
Transcription factor SMP1
Gene: SMP1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	12482976, 15448699
Identification Methods	two hybrid, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Sc			1 452
+	At
		666685 MPK4_ARATH (2-348): 6.84e-147: 424: 47.04		AGL1_ARATH (1-225): 2.62e-62: 204: 18.03
+	At
		726615 MPK4_ARATH (2-348): 6.84e-147: 424: 47.04		AP3_ARATH (1-211): 1.36e-62: 204: 21.27
+	At
		666724 MPK5_ARATH (1-348): 3.06e-142: 412: 47.47		AGL3_ARATH (1-254): 9.44e-66: 213: 21.67
+	At
		726613 MPK1_ARATH (4-353): 1.53e-143: 415: 43.86		AP3_ARATH (1-211): 1.36e-62: 204: 21.27
+	At
		666684 MPK3_ARATH (2-346): 9.22e-143: 413: 47.31		AGL1_ARATH (1-225): 2.62e-62: 204: 18.03
+	At
		726572 MPK6_ARATH (1-346): 8.92e-141: 409: 46.89		AP1_ARATH (1-230): 7.07e-64: 208: 18.60
+	At
		726614 MPK3_ARATH (2-346): 9.22e-143: 413: 47.31		AP3_ARATH (1-211): 1.36e-62: 204: 21.27
+	At
		1105016 MPK10_ARATH (1-350): 1.14e-141: 411: 44.97		AGL8_ARATH (1-180): 8.21e-62: 202: 22.34
+	At
		666686 MPK6_ARATH (1-346): 8.92e-141: 409: 46.89		AGL1_ARATH (1-225): 2.62e-62: 204: 18.03
+	Hs
		1026851 MK07_HUMAN (8-380): 1.96e-141: 425: 41.97		MEF2D_HUMAN (1-66): 1.08e-13: 75.1: 57.58
+	Hs
		987215 MK07_HUMAN (8-380): 1.96e-141: 425: 41.97		MEF2C_HUMAN (1-91): 1.69e-13: 74.3: 48.35
+	Hs
		968776 MK07_HUMAN (8-380): 1.96e-141: 425: 41.97		MEF2A_HUMAN (1-66): 2.48e-13: 73.9: 59.09
+	At
		1104847 MPK4_ARATH (2-348): 6.84e-147: 424: 47.04		AGL15_ARATH (1-72): 2.88e-12: 68.6: 48.61
+	At
		1104845 MPK1_ARATH (4-353): 1.53e-143: 415: 43.86		AGL15_ARATH (1-72): 2.88e-12: 68.6: 48.61
+	At
		1106019 MPK1_ARATH (4-353): 1.53e-143: 415: 43.86		AGL18_ARATH (1-67): 6.86e-12: 67.4: 49.25
+	At
		1104743 MPK1_ARATH (4-353): 1.53e-143: 415: 43.86		AGL11_ARATH (1-59): 7.12e-12: 67: 52.54
+	At
		1106249 MPK3_ARATH (2-346): 9.22e-143: 413: 47.31		AGL18_ARATH (1-67): 6.86e-12: 67.4: 49.25
+	At
		1104860 MPK10_ARATH (1-350): 1.14e-141: 411: 44.97		AGL15_ARATH (1-72): 2.88e-12: 68.6: 48.61
+	At
		1106496 MPK5_ARATH (1-348): 3.06e-142: 412: 47.47		AGL18_ARATH (1-67): 6.86e-12: 67.4: 49.25
+	At
		1104744 MPK6_ARATH (1-346): 8.92e-141: 409: 46.89		AGL11_ARATH (1-59): 7.12e-12: 67: 52.54