Protein: RABE1
Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17)

Gene: RABE1, RABEP1
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q15276

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005768 - endosome
GO:0005769 - early endosome
GO:0005829 - cytosol
GO:0006893 - Golgi to plasma membrane transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1144893

RABX5
Rab5 GDP/GTP exchange factor

11

6

Small-scale

0.977

High

1144894

GGA2
ADP-ribosylation factor-binding protein GGA2

8

6

Small-scale

0.977

High

1144895

GGA1
ADP-ribosylation factor-binding protein GGA1

9

6

Small-scale

0.976

High

631235

RAB5A
Ras-related protein Rab-5A

9

8

Small-scale

0.970

High

630806

RAB4A
Ras-related protein Rab-4A

7

7

Small-scale

0.964

High

1144887

GGA3
ADP-ribosylation factor-binding protein GGA3

5

7

Small-scale

0.937

High

1144814

RABE1
Rab GTPase-binding effector protein 1

2

18

Small-scale

0.836

High

976281

RB11A
Ras-related protein Rab-11A

3

4

High-throughput

0.827

High

956216

RAB4B
Ras-related protein Rab-4B

2

7

High-throughput

0.783

High

1144878

RABE2
Rab GTPase-binding effector protein 2

2

19

Small-scale

0.776

High

966338

1433G
14-3-3 protein gamma

6

20

High-throughput

0.732

High

225813

AP1G1
AP-1 complex subunit gamma-1

6

6

Small-scale

0.729

High

1144897

RAB21
Ras-related protein Rab-21

1

10

High-throughput

0.691

High

729857

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

691028

1433T
14-3-3 protein theta

4

20

High-throughput

0.687

High

1049313

1433F
14-3-3 protein eta

4

20

High-throughput

0.678

High

990253

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.662

High

508008

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

12

High-throughput

0.655

High

900827

RAB5C
Ras-related protein Rab-5C

1

9

Small-scale

0.647

High

981281

RAB1A
Ras-related protein Rab-1A

1

3

Small-scale

0.647

High

1144873

RB33B
Ras-related protein Rab-33B

1

5

Small-scale

0.647

High

1144889

ITSN2
Intersectin-2

2

5

Small-scale

0.633

High

451162

NFL
Neurofilament light polypeptide

2

11

High-throughput

0.628

High

1144879

SYNCI
Syncoilin

2

5

High-throughput

0.628

High

1144885

EXOC1
Exocyst complex component 1

2

1

High-throughput

0.628

High

901825

RAB9A
Ras-related protein Rab-9A

1

7

High-throughput

0.618

High

944998

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.618

High

342880

HERC2
E3 ubiquitin-protein ligase HERC2

2

6

High-throughput

0.611

High

971551

1433E
14-3-3 protein epsilon

2

2

High-throughput

0.611

High

1135331

SLMAP
Sarcolemmal membrane-associated protein

3

19

High-throughput

0.609

High

1144824

CC183
Coiled-coil domain-containing protein 183

3

11

High-throughput

0.609

High

215105

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

1

High-throughput

0.606

High

1144825

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

2

4

High-throughput

0.606

High

1144831

CDC73
Parafibromin

2

2

High-throughput

0.606

High

1144840

ZN438
Zinc finger protein 438

2

3

High-throughput

0.606

High

1144849

TENS4
Tensin-4

2

3

High-throughput

0.606

High

1144862

CC120
Coiled-coil domain-containing protein 120

2

2

High-throughput

0.606

High

1144867

BARD1
BRCA1-associated RING domain protein 1

2

5

High-throughput

0.606

High

1144886

ABI2
Abl interactor 2

2

13

High-throughput

0.606

High

1144818

TM266
Transmembrane protein 266

2

0

High-throughput

0.602

High

295739

AP1G2
AP-1 complex subunit gamma-like 2

2

6

Small-scale

0.601

High

1096547

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

0

High-throughput

0.580

High

1144842

CEP57
Centrosomal protein of 57 kDa

2

0

High-throughput

0.580

High

1144880

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

0

High-throughput

0.580

High

1144888

MAT2B
Methionine adenosyltransferase 2 subunit beta

2

0

High-throughput

0.580

High

1144898

TPC2L
Trafficking protein particle complex subunit 2-like protein

2

0

High-throughput

0.580

High

1144901

WASC3
WASH complex subunit 3

2

0

High-throughput

0.580

High

63295

ODAD3
Outer dynein arm-docking complex subunit 3

2

19

High-throughput

0.553

High

288412

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

14

High-throughput

0.553

High

506159

UBFL1
Upstream-binding factor 1-like protein 1

2

6

High-throughput

0.553

High

1057607

CDK18
Cyclin-dependent kinase 18

2

13

High-throughput

0.553

High

1110995

SNW1
SNW domain-containing protein 1

2

2

High-throughput

0.553

High

1124333

ELOA1
Elongin-A

2

7

High-throughput

0.553

High

1144830

ZN774
Zinc finger protein 774

2

2

High-throughput

0.553

High

1144845

CDKL3
Cyclin-dependent kinase-like 3

2

17

High-throughput

0.553

High

1144863

Z512B
Zinc finger protein 512B

2

9

High-throughput

0.553

High

1144865

CFA53
Cilia- and flagella-associated protein 53

2

11

High-throughput

0.553

High

1144868

PKP2
Plakophilin-2

2

13

High-throughput

0.553

High

1144875

RNF39
RING finger protein 39

2

9

High-throughput

0.553

High

1144884

TSH2
Teashirt homolog 2

2

3

High-throughput

0.553

High

333337

SNAPN
SNARE-associated protein Snapin

1

3

High-throughput

0.541

High

873962

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

1089205

TRI26
Tripartite motif-containing protein 26

1

8

High-throughput

0.541

High

252765

AP180
Clathrin coat assembly protein AP180

1

6

High-throughput

0.536

High

330988

KI20A
Kinesin-like protein KIF20A

1

19

High-throughput

0.536

High

625396

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.536

High

721005

CLIP1
CAP-Gly domain-containing linker protein 1

1

16

High-throughput

0.536

High

777473

K22E
Keratin, type II cytoskeletal 2 epidermal

1

2

High-throughput

0.536

High

1035507

CENPE
Centromere-associated protein E

1

1

High-throughput

0.536

High

1144833

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

6

High-throughput

0.536

High

1144839

K1C27
Keratin, type I cytoskeletal 27

1

4

High-throughput

0.536

High

1144851

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

3

High-throughput

0.536

High

1144854

SMRC1
SWI/SNF complex subunit SMARCC1

1

4

High-throughput

0.536

High

1144856

EXOC4
Exocyst complex component 4

1

1

High-throughput

0.536

High

1144857

SH3K1
SH3 domain-containing kinase-binding protein 1

1

11

High-throughput

0.536

High

1144864

HSFY1
Heat shock transcription factor, Y-linked

1

2

High-throughput

0.536

High

1144869

KXDL1
KxDL motif-containing protein 1

1

1

High-throughput

0.536

High

1144896

RCOR1
REST corepressor 1

2

4

High-throughput

0.533

High

1144890

RGS17
Regulator of G-protein signaling 17

1

0

High-throughput

0.518

High

184713

ATX7
Ataxin-7

1

5

High-throughput

0.508

High

1006417

SRPK2
SRSF protein kinase 2

1

13

High-throughput

0.501

High

1144881

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

Small-scale

0.501

High

584023

FOSL1
Fos-related antigen 1

1

2

High-throughput

0.489

High

1144819

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

1144836

R9BP
Regulator of G-protein signaling 9-binding protein

1

1

High-throughput

0.489

High

1144838

CC186
Coiled-coil domain-containing protein 186

1

17

High-throughput

0.489

High

1144847

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

1144860

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

9

High-throughput

0.489

High

1144866

TMM74
Transmembrane protein 74

1

1

High-throughput

0.489

High

1144899

HSF4
Heat shock factor protein 4

1

1

High-throughput

0.489

High

664747

CCND1
G1/S-specific cyclin-D1

1

1

High-throughput

0.481

High

791401

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

1144815

ITSN1
Intersectin-1

1

5

High-throughput

0.481

High

1144827

ECM29
Proteasome adapter and scaffold protein ECM29

1

10

Small-scale

0.481

High

179904

BET1
BET1 homolog

1

2

High-throughput

0.479

High

192924

CLOCK
Circadian locomoter output cycles protein kaput

1

9

High-throughput

0.479

High

218207

TGON2
Trans-Golgi network integral membrane protein 2

1

7

High-throughput

0.479

High

226036

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

246615

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.479

High

411972

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

413877

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

437182

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

459601

PROF1
Profilin-1

1

1

High-throughput

0.479

High

483096

CLCA
Clathrin light chain A

1

3

High-throughput

0.479

High

529838

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.479

High

541500

FGFR1
Fibroblast growth factor receptor 1

1

7

High-throughput

0.479

High

560401

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

582806

EZRI
Ezrin

1

9

High-throughput

0.479

High

862151

YAP1
Transcriptional coactivator YAP1

1

16

High-throughput

0.479

High

891170

GSK3A
Glycogen synthase kinase-3 alpha

1

15

High-throughput

0.479

High

891568

GSK3B
Glycogen synthase kinase-3 beta

1

17

High-throughput

0.479

High

896531

VASP
Vasodilator-stimulated phosphoprotein

1

4

High-throughput

0.479

High

960121

RL26
Large ribosomal subunit protein uL24

1

2

High-throughput

0.479

High

1031380

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

1109747

HDAC1
Histone deacetylase 1

1

15

High-throughput

0.479

High

1122393

GIT2
ARF GTPase-activating protein GIT2

1

9

High-throughput

0.479

High

1141622

EEA1
Early endosome antigen 1

1

19

Small-scale

0.479

High

1144816

ZYX
Zyxin

1

3

High-throughput

0.479

High

1144817

CCDC6
Coiled-coil domain-containing protein 6

1

18

High-throughput

0.479

High

1144821

GRAP1
GRIP1-associated protein 1

1

18

High-throughput

0.479

High

1144828

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.479

High

1144832

PKN3
Serine/threonine-protein kinase N3

1

10

High-throughput

0.479

High

1144841

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1144852

GOGA5
Golgin subfamily A member 5

1

19

High-throughput

0.479

High

1144853

CCHCR
Coiled-coil alpha-helical rod protein 1

1

18

High-throughput

0.479

High

1144870

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.479

High

1144871

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

1144872

WWTR1
WW domain-containing transcription regulator protein 1

1

15

High-throughput

0.479

High

1144876

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

1

Small-scale

0.479

High

1144891

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1144892

PUF60
Poly(U)-binding-splicing factor PUF60

1

8

High-throughput

0.479

High

426500

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.470

High

128431

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.458

High

278864

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

290005

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

1144826

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.458

High

1144874

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

607301

NEUM
Neuromodulin

1

1

Small-scale

0.457

High

943579

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

4

Small-scale

0.439

High

566902

CO6
Complement component C6

1

3

High-throughput

0.437

High

588755

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

711896

LTK
Leukocyte tyrosine kinase receptor

1

10

High-throughput

0.437

High

1121221

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.437

High

1144834

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1144835

LMTK1
Serine/threonine-protein kinase LMTK1

1

13

High-throughput

0.437

High

1144837

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1144843

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

17

High-throughput

0.437

High

1144858

PF21A
PHD finger protein 21A

1

11

High-throughput

0.437

High

1144877

ESF1
ESF1 homolog

1

1

High-throughput

0.437

High

1144883

TUFT1
Tuftelin

1

2

High-throughput

0.437

High

1144846

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

0

High-throughput

0.426

High

1144855

STMN2
Stathmin-2

1

0

High-throughput

0.426

High

885939

STAR
Steroidogenic acute regulatory protein, mitochondrial

2

0

High-throughput

0.316

High

1144822

ESCO2
N-acetyltransferase ESCO2

2

0

High-throughput

0.316

High

1144844

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1144859

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.316

High

1144861

MCRS1
Microspherule protein 1

2

0

High-throughput

0.316

High

1144900

FA50B
Protein FAM50B

2

0

High-throughput

0.316

High

1144823

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

1144848

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

1144850

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.279

Low

85262

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

340330

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.249

Low

503585

TFPT
TCF3 fusion partner

1

0

High-throughput

0.249

Low

1144820

KMT5B
Histone-lysine N-methyltransferase KMT5B

1

0

High-throughput

0.249

Low

1144829

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1144882

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025