HitPredict

Interactor 1: SEC17 (P32602)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) (Vesicular-fusion protein SEC17) (alpha-SNAP chaperone)
Gene: SEC17

Interactor 2: GOSR1 (P38736)
Golgi SNAP receptor complex member 1 (Golgi SNARE protein 1) (Protein transport protein GOS1)
Gene: GOS1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	9755865, 35904239
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006886 - intracellular protein transport GO:0031201 - SNARE complex GO:0048280 - vesicle fusion with Golgi apparatus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 292 Sc			1 223
+	Hs
		309572 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		GOSR1_HUMAN (3-222): 1.09e-64: 202: 22.54
+	Hs
		103894 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		G5E9T8_HUMAN (9-222): 4.14e-62: 196: 23.11
+	Dm
		1095572 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		GOSR1_DROME (5-222): 1.56e-49: 163: 21.40
+	Hs
		873571 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		VTI1A_HUMAN (17-223): 5.42e-48: 158: 13.81
+	Dm
		1095589 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		Q9W0N6_DROME (16-219): 4.88e-41: 141: 14.01
+	Sc
		630922 SEC17_YEAST (1-292): 5.94e-97: 288: 100.00		BOS1_YEAST (9-208): 1.12e-39: 138: 14.73
+	Sc
		696593 SEC17_YEAST (1-292): 5.94e-97: 288: 100.00		VTI1_YEAST (15-209): 6.59e-35: 125: 14.65
+	Hs
		151556 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		GOSR2_HUMAN (8-221): 5.29e-30: 112: 10.19
+	Dm
		1095583 SNAP_DROME (3-289): 9.54e-100: 295: 32.40		GOSR2_DROME (16-223): 3.7e-23: 94.5: 16.28
+	Hs
		873593 SNAA_HUMAN (12-291): 5.14e-101: 299: 35.00		VTI1B_HUMAN (36-205): 1.15e-16: 77.5: 12.14
+	Hs
		1284294 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		VTI1A_HUMAN (17-223): 5.42e-48: 158: 13.81
+	Dm
		1353738 Q9U6R9_DROME (1-262): 1.1e-59: 194: 21.29		GOSR1_DROME (5-222): 1.56e-49: 163: 21.40
+	Dm
		1364296 Q9VH25_DROME (23-262): 3.76e-56: 184: 21.49		GOSR1_DROME (5-222): 1.56e-49: 163: 21.40
+	Dm
		1353753 Q9U6R9_DROME (1-262): 1.1e-59: 194: 21.29		Q9W0N6_DROME (16-219): 4.88e-41: 141: 14.01
+	Dm
		1366630 Q9VH25_DROME (23-262): 3.76e-56: 184: 21.49		Q9W0N6_DROME (16-219): 4.88e-41: 141: 14.01
+	Hs
		1306213 SNAG_HUMAN (1-248): 1.09e-67: 214: 21.20		VTI1B_HUMAN (36-205): 1.15e-16: 77.5: 12.14
+	Dm
		1353746 Q9U6R9_DROME (1-262): 1.1e-59: 194: 21.29		GOSR2_DROME (16-223): 3.7e-23: 94.5: 16.28
+	Dm
		1366625 Q9VH25_DROME (23-262): 3.76e-56: 184: 21.49		GOSR2_DROME (16-223): 3.7e-23: 94.5: 16.28