HitPredict

Interactor 1: PYR1 (P27708)
Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]
Gene: CAD

Interactor 2: HDAC6 (Q9UBN7)
Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35676659, 23703321
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0019899 - enzyme binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 2225 Hs			1 1215
+	Hs
		697527 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC1_HUMAN (80-482): 4.66e-166: 503: 20.71
+	Hs
		697607 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Hs
		697692 PYR1_HUMAN (1-2225): 0: 2858: 100.00		HDAC5_HUMAN (33-471): 8.24e-146: 471: 32.48
+	Hs
		725671 CPSM_HUMAN (2-1448): 0: 1507: 50.61		HDAC6_HUMAN (1-1215): 0: 1440: 100.00
+	Hs
		725632 CPSM_HUMAN (2-1448): 0: 1507: 50.61		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74
+	Hs
		1158691 DPYL2_HUMAN (1397-1915): 1.02e-161: 512: 17.78		HDAC2_HUMAN (78-489): 3.62e-158: 483: 20.74