HitPredict

Interactor 1: GSP1 (P32835)
GTP-binding nuclear protein GSP1/CNR1 (Chromosome stability protein 17) (GTPase Ran homolog) (Genetic suppressor of PRP20-1)
Gene: GSP1

Interactor 2: IMB2 (P38217)
Importin subunit beta-2 (Importin-104) (Karyopherin subunit beta-2) (Karyopherin-104) (Transportin) (TRN)
Gene: KAP104

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.731

Property	Details
Experiments	11251069, 11805837, 25144938, 15679097, 17485461, 21329658
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 219 Sc			1 918
+	Sc
		699003 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		IMB2_YEAST (1-918): 0: 580: 100.00
+	Dm
		1373317 RANL_DROME (13-219): 2.1e-90: 266: 59.42		Q9VRV8_DROME (3-862): 1.24e-171: 523: 32.15
+	Hs
		919198 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO1_HUMAN (1-864): 7.94e-177: 537: 33.03
+	Hs
		155560 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		TNPO2_HUMAN (3-862): 2.26e-166: 510: 31.89
+	At
		784988 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		TNPO1_ARATH (2-865): 6.75e-148: 461: 27.96
+	At
		784992 RAN1_ARATH (1-216): 6.84e-94: 275: 75.58		IMB1_ARATH (11-888): 1.66e-97: 327: 12.86
+	At
		784999 RAN2_ARATH (1-216): 1.74e-88: 261: 75.58		IMB1_ARATH (11-888): 1.66e-97: 327: 12.86
+	At
		1210454 RAN3_ARATH (1-219): 5.37e-84: 250: 74.55		IMB1_ARATH (11-888): 1.66e-97: 327: 12.86
+	Hs
		919182 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO4_HUMAN (50-802): 3.97e-99: 336: 14.76
+	Hs
		919077 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IMB1_HUMAN (13-885): 1.66e-97: 327: 11.77
+	Sc
		687908 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		IMB3_YEAST (9-858): 2.92e-90: 311: 15.32
+	Sc
		687909 GSP2_YEAST (1-219): 9.33e-78: 234: 96.82		IMB3_YEAST (9-858): 2.92e-90: 311: 15.32
+	Hs
		874484 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		XPO2_HUMAN (6-846): 4.85e-90: 309: 11.34
+	Sc
		698945 GSP1_YEAST (1-219): 1.49e-79: 239: 100.00		IMB1_YEAST (14-865): 3.48e-86: 296: 12.25
+	Hs
		312234 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO7_HUMAN (13-840): 6.5e-84: 293: 13.20
+	Hs
		236414 RB11A_HUMAN (1-207): 4.63e-79: 237: 26.17		RNBP6_HUMAN (109-887): 7.22e-23: 107: 11.90
+	Hs
		127238 RAN_HUMAN (1-216): 3.71e-76: 230: 80.56		IPO5_HUMAN (18-886): 1.81e-23: 109: 10.47