HitPredict

Interactor 1: CALX (P27824)
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene: CANX

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25147182, 37167062
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 4374
+	Mm
		772444 CALX_MOUSE (1-592): 0: 732: 90.56		HUWE1_MOUSE (1-4374): 0: 3269: 96.41
+	Hs
		697934 CALR_HUMAN (67-470): 1.2e-141: 418: 38.33		HUWE1_HUMAN (1-4374): 0: 3307: 100.00
+	Hs
		699010 CALX_HUMAN (1-592): 0: 786: 100.00		ITCH_HUMAN (3507-4372): 0: 670: 23.27
+	Hs
		699143 CALX_HUMAN (1-592): 0: 786: 100.00		SMUF2_HUMAN (3802-4371): 0: 615: 34.33
+	Hs
		697796 CALR_HUMAN (67-470): 1.2e-141: 418: 38.33		NEDD4_HUMAN (3130-4372): 0: 612: 21.39