HitPredict

Interactor 1: SMC1 (P32908)
Structural maintenance of chromosomes protein 1 (DA-box protein SMC1)
Gene: SMC1

Interactor 2: SMC3 (P47037)
Structural maintenance of chromosomes protein 3 (DA-box protein SMC3)
Gene: SMC3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 11087867, 11805826, 11805837, 11983169, 9990856, 14614818, 16554755, 16429126, 27692962, 26895426, 17660750, 31807710, 34259632, 37166686, 37739959, 37968396, 20153193, 21139566, 21441928, 14613943 and 4 others

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Identification Methods two hybrid, tandem affinity purification, anti tag coimmunoprecipitation, affinity chromatography technology, pull down, biochemical, fluorescent resonance energy transfer, x-ray crystallography, surface plasmon resonance, isothermal titration calorimetry and 1 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SMC_hinge~SMC_hinge, SMC_N~SMC_N
Common GO terms GO:0003690 - double-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0007064 - mitotic sister chromatid cohesion
GO:0016887 - ATP hydrolysis activity
and 5 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1225
Sc

1 1230
+ Hs
+ Mm
+ Bt
+ Hs
+ Xl
+ Xl
+ Mm
+ Sc
+ Sc
+ Sc
+ Hs
+ Hs
+ Mm
+ Xl
+ Ce
+ Sp
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024