Protein: DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)

Gene: DQA1, HLA-DQA1
Organism: Homo sapiens
Interactions: 139
UniProt ID: P01909

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002250 - adaptive immune response
GO:0002503 - peptide antigen assembly with MHC class II protein complex
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

380393

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

4

20

Small-scale

0.908

High

380394

HG2A
HLA class II histocompatibility antigen gamma chain

2

9

Small-scale

0.754

High

193662

TPSN
Tapasin

1

20

High-throughput

0.691

High

380237

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

19

High-throughput

0.691

High

380391

DQA2
HLA class II histocompatibility antigen, DQ alpha 2 chain

1

19

High-throughput

0.691

High

380396

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

19

High-throughput

0.691

High

380400

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

19

High-throughput

0.691

High

380415

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

19

High-throughput

0.691

High

380436

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

1

19

High-throughput

0.691

High

380468

IGSF8
Immunoglobulin superfamily member 8

1

3

High-throughput

0.691

High

127620

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

0

High-throughput

0.656

High

380399

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.656

High

380416

EFNB1
Ephrin-B1

3

3

High-throughput

0.656

High

380429

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

3

2

High-throughput

0.656

High

380451

TM219
Insulin-like growth factor-binding protein 3 receptor

3

1

High-throughput

0.656

High

380460

MFSD8
Major facilitator superfamily domain-containing protein 8

3

8

High-throughput

0.656

High

380491

ST7
Suppressor of tumorigenicity 7 protein

3

2

High-throughput

0.656

High

380395

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

19

High-throughput

0.618

High

380403

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

6

High-throughput

0.618

High

380466

VPP1
V-type proton ATPase 116 kDa subunit a 1

2

1

High-throughput

0.611

High

380470

S67A1
Solute carrier family 67 member A1

2

9

High-throughput

0.611

High

380477

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

2

3

High-throughput

0.611

High

380498

DD19B
ATP-dependent RNA helicase DDX19B

2

1

High-throughput

0.611

High

380502

S27A6
Long-chain fatty acid transport protein 6

2

3

High-throughput

0.611

High

380504

VPP2
V-type proton ATPase 116 kDa subunit a 2

2

1

High-throughput

0.611

High

380410

CUX1
Homeobox protein cut-like 1

3

3

High-throughput

0.599

High

380445

TM214
Transmembrane protein 214

3

2

High-throughput

0.599

High

380447

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

3

4

High-throughput

0.599

High

380401

CD8B
T-cell surface glycoprotein CD8 beta chain

1

0

High-throughput

0.586

High

380457

S38A9
Neutral amino acid transporter 9

2

1

High-throughput

0.584

High

380472

MYO19
Unconventional myosin-XIX

2

3

High-throughput

0.584

High

379823

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

20

High-throughput

0.575

High

380455

MACOI
Macoilin

2

1

High-throughput

0.558

High

380412

CDK7
Cyclin-dependent kinase 7

1

4

High-throughput

0.541

High

380475

SH3G2
Endophilin-A1

1

1

High-throughput

0.541

High

380507

NEMO
NF-kappa-B essential modulator

1

2

High-throughput

0.541

High

61074

T131L
Transmembrane protein 131-like

1

9

High-throughput

0.536

High

173827

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

11

High-throughput

0.536

High

212048

B4GT5
Beta-1,4-galactosyltransferase 5

1

3

High-throughput

0.536

High

230736

EXTL3
Exostosin-like 3

1

7

High-throughput

0.536

High

249400

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

4

High-throughput

0.536

High

253806

TPST2
Protein-tyrosine sulfotransferase 2

1

1

High-throughput

0.536

High

269648

PLXA2
Plexin-A2

1

19

High-throughput

0.536

High

270130

FKTN
Ribitol-5-phosphate transferase FKTN

1

1

High-throughput

0.536

High

292514

RENR
Renin receptor

1

2

High-throughput

0.536

High

337521

LARG1
Xylosyl- and glucuronyltransferase LARGE1

1

6

High-throughput

0.536

High

341270

ECEL1
Endothelin-converting enzyme-like 1

1

8

High-throughput

0.536

High

343831

SEM4F
Semaphorin-4F

1

12

High-throughput

0.536

High

380402

ADT1
ADP/ATP translocase 1

1

9

High-throughput

0.536

High

380404

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

1

High-throughput

0.536

High

380406

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

3

High-throughput

0.536

High

380408

CALX
Calnexin

1

11

High-throughput

0.536

High

380409

SCNNA
Epithelial sodium channel subunit alpha

1

14

High-throughput

0.536

High

380411

MA2A2
Alpha-mannosidase 2x

1

4

High-throughput

0.536

High

380414

PLXA3
Plexin-A3

1

15

High-throughput

0.536

High

380419

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.536

High

380421

HYAL2
Hyaluronidase-2

1

1

High-throughput

0.536

High

380423

STIM1
Stromal interaction molecule 1

1

4

High-throughput

0.536

High

380424

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

4

High-throughput

0.536

High

380425

MOGS
Mannosyl-oligosaccharide glucosidase

1

1

High-throughput

0.536

High

380427

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.536

High

380430

VAS1
V-type proton ATPase subunit S1

1

1

High-throughput

0.536

High

380431

EXT1
Exostosin-1

1

7

High-throughput

0.536

High

380432

MA2A1
Alpha-mannosidase 2

1

4

High-throughput

0.536

High

380446

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

9

High-throughput

0.536

High

380448

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

3

High-throughput

0.536

High

380449

GALT7
N-acetylgalactosaminyltransferase 7

1

9

High-throughput

0.536

High

380450

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

4

High-throughput

0.536

High

380452

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

9

High-throughput

0.536

High

380453

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

3

High-throughput

0.536

High

380454

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

5

High-throughput

0.536

High

380458

CHSTE
Carbohydrate sulfotransferase 14

1

11

High-throughput

0.536

High

380459

NLGN2
Neuroligin-2

1

2

High-throughput

0.536

High

380461

GPX8
Probable glutathione peroxidase 8

1

2

High-throughput

0.536

High

380462

SCRB1
Scavenger receptor class B member 1

1

4

High-throughput

0.536

High

380465

EDA
Ectodysplasin-A

1

1

High-throughput

0.536

High

380467

PIGT
GPI-anchor transamidase component PIGT

1

1

High-throughput

0.536

High

380479

CNTP3
Contactin-associated protein-like 3

1

4

High-throughput

0.536

High

380480

ABCA2
ATP-binding cassette sub-family A member 2

1

5

High-throughput

0.536

High

380481

SEM4C
Semaphorin-4C

1

12

High-throughput

0.536

High

380482

LMA2L
VIP36-like protein

1

2

High-throughput

0.536

High

380484

SPNS1
Protein spinster homolog 1

1

1

High-throughput

0.536

High

380485

SEM6B
Semaphorin-6B

1

12

High-throughput

0.536

High

380486

S38AA
Solute carrier family 38 member 10

1

5

High-throughput

0.536

High

380488

AT132
Polyamine-transporting ATPase 13A2

1

14

High-throughput

0.536

High

380490

ITM2C
Integral membrane protein 2C

1

8

High-throughput

0.536

High

380492

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

9

High-throughput

0.536

High

380495

LCAP
Leucyl-cystinyl aminopeptidase

1

10

High-throughput

0.536

High

380496

PLXA1
Plexin-A1

1

14

High-throughput

0.536

High

380497

DSE
Dermatan-sulfate epimerase

1

2

High-throughput

0.536

High

380503

DOP1B
Protein DOP1B

1

1

High-throughput

0.536

High

380505

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

7

High-throughput

0.536

High

380506

S12A7
Solute carrier family 12 member 7

1

2

High-throughput

0.536

High

380397

GALT
Galactose-1-phosphate uridylyltransferase

2

1

High-throughput

0.533

High

380413

APLP1
Amyloid beta precursor like protein 1

1

0

High-throughput

0.518

High

380398

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.513

High

380417

B4GN1
Beta-1,4 N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.513

High

380434

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.513

High

380444

RRAGB
Ras-related GTP-binding protein B

1

0

High-throughput

0.513

High

380464

CCL17
C-C motif chemokine 17

1

0

High-throughput

0.513

High

380476

APOL2
Apolipoprotein L2

1

0

High-throughput

0.513

High

380483

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

380489

GPC5C
G-protein coupled receptor family C group 5 member C

1

0

High-throughput

0.513

High

380499

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.513

High

380420

TLE1
Transducin-like enhancer protein 1

1

2

High-throughput

0.494

High

49425

TM223
Transmembrane protein 223

1

2

High-throughput

0.489

High

282553

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.489

High

337243

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

1

4

High-throughput

0.489

High

337663

SGPL1
Sphingosine-1-phosphate lyase 1

1

2

High-throughput

0.489

High

380407

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

3

High-throughput

0.489

High

380428

UBE3C
Ubiquitin-protein ligase E3C

1

2

High-throughput

0.489

High

380433

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

6

High-throughput

0.489

High

380435

VWC2
Brorin

1

2

High-throughput

0.489

High

380439

MKS3
Meckelin

1

6

High-throughput

0.489

High

380440

TM201
Transmembrane protein 201

1

2

High-throughput

0.489

High

380456

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.489

High

380463

ELYS
Protein ELYS

1

3

High-throughput

0.489

High

380471

TECT2
Tectonic-2

1

6

High-throughput

0.489

High

380473

P121A
Nuclear envelope pore membrane protein POM 121

1

4

High-throughput

0.489

High

380478

PXL2A
Peroxiredoxin-like 2A

1

2

High-throughput

0.489

High

380494

PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

1

1

High-throughput

0.489

High

380500

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

2

High-throughput

0.489

High

380501

DJC16
DnaJ homolog subfamily C member 16

1

10

High-throughput

0.489

High

261048

NSMA
Sphingomyelin phosphodiesterase 2

1

3

High-throughput

0.479

High

380418

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

1

High-throughput

0.479

High

380469

T106A
Transmembrane protein 106A

1

15

High-throughput

0.479

High

380443

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.457

High

380426

CASP
Protein CASP

1

4

High-throughput

0.445

High

380487

SEM4B
Semaphorin-4B

1

12

High-throughput

0.445

High

380405

COT2
COUP transcription factor 2

1

3

High-throughput

0.437

High

380493

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.437

High

380422

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.282

High

221437

OREX
Hypocretin neuropeptide precursor

1

0

High-throughput

0.279

Low

302231

STC2
Stanniocalcin-2

1

0

High-throughput

0.279

Low

380437

DB110
Beta-defensin 110

1

0

High-throughput

0.279

Low

380438

MBRL
Membralin

1

0

High-throughput

0.279

Low

380442

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.279

Low

380474

CP2S1
Cytochrome P450 2S1

1

0

High-throughput

0.279

Low

380441

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025