Protein: S12A7
Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4)

Gene: S12A7, SLC12A7
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q9Y666

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006811 - monoatomic ion transport
GO:0006884 - cell volume homeostasis
GO:0007268 - chemical synaptic transmission
GO:0015379 - potassium:chloride symporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1462446

S12A4
Solute carrier family 12 member 4

3

13

High-throughput

0.830

High

1460119

S12A6
Solute carrier family 12 member 6

2

12

Small-scale

0.737

High

609855

LEG3
Galectin-3

5

20

High-throughput

0.709

High

376155

RASK
GTPase KRas

3

20

High-throughput

0.640

High

125682

LEG9
Galectin-9

4

20

High-throughput

0.630

High

845551

PI2R
Prostacyclin receptor

2

8

High-throughput

0.628

High

1406374

GPR21
Probable G-protein coupled receptor 21

2

8

High-throughput

0.628

High

1428340

NMUR2
Neuromedin-U receptor 2

2

9

High-throughput

0.628

High

1446237

NRN1
Neuritin

2

2

High-throughput

0.628

High

1454435

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

20

High-throughput

0.628

High

127420

LEG8
Galectin-8

3

20

High-throughput

0.609

High

1231713

LEG9C
Galectin-9C

3

20

High-throughput

0.609

High

832381

OPRD
Delta-type opioid receptor

2

12

High-throughput

0.606

High

934303

BI1
Bax inhibitor 1

2

2

High-throughput

0.606

High

1134191

NTCP
Hepatic sodium/bile acid cotransporter

2

4

High-throughput

0.606

High

1186080

SOAT
Sodium-dependent organic anion transporter

2

4

High-throughput

0.606

High

1205550

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

1

High-throughput

0.606

High

1400576

TM237
Transmembrane protein 237

2

2

High-throughput

0.606

High

1419995

GPR61
G-protein coupled receptor 61

2

4

High-throughput

0.606

High

374310

RASN
GTPase NRas

2

20

High-throughput

0.584

High

978436

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

1415458

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

1432291

S12A5
Solute carrier family 12 member 5

1

14

High-throughput

0.575

High

1359381

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

5

High-throughput

0.574

High

464729

CXB1
Gap junction beta-1 protein

2

8

High-throughput

0.553

High

1220549

OTP
Homeobox protein orthopedia

2

1

High-throughput

0.553

High

1388824

YIPF6
Protein YIPF6

2

7

High-throughput

0.553

High

1447184

S35C2
Solute carrier family 35 member C2

2

2

High-throughput

0.553

High

171041

CLGN
Calmegin

2

11

High-throughput

0.549

High

142172

NPT3
Sodium-dependent phosphate transport protein 3

1

4

High-throughput

0.536

High

190529

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.536

High

248524

O10H2
Olfactory receptor 10H2

1

11

High-throughput

0.536

High

380506

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

2

High-throughput

0.536

High

480943

LEG1
Galectin-1

1

20

High-throughput

0.536

High

549927

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

3

High-throughput

0.536

High

575713

GPIX
Platelet glycoprotein IX

1

1

High-throughput

0.536

High

663536

FSHR
Follicle-stimulating hormone receptor

1

7

High-throughput

0.536

High

750573

CP2CI
Cytochrome P450 2C18

1

3

High-throughput

0.536

High

1116855

AVR2B
Activin receptor type-2B

1

3

High-throughput

0.536

High

1203854

TTMP
TPA-induced transmembrane protein

1

4

High-throughput

0.536

High

1277750

TMC4
Voltage-gated chloride channel TMC4

1

2

High-throughput

0.536

High

1328501

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

4

High-throughput

0.536

High

1333628

SIDT2
SID1 transmembrane family member 2

1

2

High-throughput

0.536

High

1339955

OR4N2
Olfactory receptor 4N2

1

9

High-throughput

0.536

High

1390954

TSN17
Tetraspanin-17

1

9

High-throughput

0.536

High

1432464

TTYH1
Protein tweety homolog 1

1

5

High-throughput

0.536

High

1438499

RXFP1
Relaxin receptor 1

1

4

High-throughput

0.536

High

1491376

O10H1
Olfactory receptor 10H1

1

11

High-throughput

0.536

High

1491550

PCDB3
Protocadherin beta-3

1

6

High-throughput

0.536

High

1491806

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

1438438

POPD2
Popeye domain-containing protein 2

2

3

High-throughput

0.521

High

252390

GFRA3
GDNF family receptor alpha-3

1

0

High-throughput

0.513

High

935388

IOD3
Thyroxine 5-deiodinase

1

0

High-throughput

0.513

High

1212115

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.513

High

1254093

LRC55
Leucine-rich repeat-containing protein 55

1

0

High-throughput

0.513

High

1349196

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1381829

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

0

High-throughput

0.513

High

1412841

TM204
Transmembrane protein 204

1

0

High-throughput

0.513

High

49832

CLRN2
Clarin-2

1

3

High-throughput

0.489

High

230724

NKG2F
NKG2-F type II integral membrane protein

1

2

High-throughput

0.489

High

317104

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

1

2

High-throughput

0.489

High

699299

CALX
Calnexin

1

11

High-throughput

0.489

High

946610

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.489

High

1126397

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

4

High-throughput

0.489

High

1185371

LEG9B
Galectin-9B

1

20

High-throughput

0.489

High

1392319

ZDH12
Palmitoyltransferase ZDHHC12

1

8

High-throughput

0.489

High

1433434

CSTN2
Calsyntenin-2

1

3

High-throughput

0.489

High

1454535

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

4

High-throughput

0.489

High

1491136

TMED7
Transmembrane emp24 domain-containing protein 7

1

15

High-throughput

0.489

High

1491716

SRPRB
Signal recognition particle receptor subunit beta

1

10

High-throughput

0.489

High

126899

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

189956

STX7
Syntaxin-7

1

13

High-throughput

0.479

High

219024

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

226284

STX6
Syntaxin-6

1

7

High-throughput

0.479

High

299449

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

341185

DIRA3
GTP-binding protein Di-Ras3

1

14

High-throughput

0.479

High

375053

RASH
GTPase HRas

1

20

High-throughput

0.479

High

463869

LYN
Tyrosine-protein kinase Lyn

1

9

High-throughput

0.479

High

466549

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

540780

LAMP1
Lysosome-associated membrane glycoprotein 1

1

11

High-throughput

0.479

High

581401

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

601520

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

604293

CXA1
Gap junction alpha-1 protein

1

8

High-throughput

0.479

High

631598

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.479

High

710595

EPHA2
Ephrin type-A receptor 2

1

16

High-throughput

0.479

High

715868

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

901121

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.479

High

901717

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.479

High

902169

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

910273

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

953783

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955801

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

962683

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

962872

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

975349

ARF6
ADP-ribosylation factor 6

1

8

High-throughput

0.479

High

976700

RB11A
Ras-related protein Rab-11A

1

8

High-throughput

0.479

High

988863

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1015945

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1041395

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

1042795

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

11

High-throughput

0.479

High

1087356

STX4
Syntaxin-4

1

14

High-throughput

0.479

High

1145201

RAB35
Ras-related protein Rab-35

1

15

High-throughput

0.479

High

1151953

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1159926

OCLN
Occludin

1

3

High-throughput

0.479

High

1233617

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.479

High

1271071

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1323060

CXD3
Gap junction delta-3 protein

1

8

High-throughput

0.479

High

1366925

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1396670

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1433604

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1438275

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1402504

SERC2
Serine incorporator 2

1

0

High-throughput

0.460

High

222335

PSCA
Prostate stem cell antigen

1

1

High-throughput

0.445

High

462089

HS90A
Heat shock protein HSP 90-alpha

1

13

High-throughput

0.445

High

468963

HS90B
Heat shock protein HSP 90-beta

1

13

High-throughput

0.445

High

484253

PGFRB
Platelet-derived growth factor receptor beta

1

6

High-throughput

0.445

High

507442

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.445

High

539757

ACHB
Acetylcholine receptor subunit beta

1

5

High-throughput

0.445

High

731746

STIP1
Stress-induced-phosphoprotein 1

1

12

High-throughput

0.445

High

868069

OR1D4
Olfactory receptor 1D4

1

5

High-throughput

0.445

High

1060411

SLC31
Amino acid transporter heavy chain SLC3A1

1

4

High-throughput

0.445

High

1158629

CDC37
Hsp90 co-chaperone Cdc37

1

3

High-throughput

0.445

High

1207916

S27A3
Long-chain fatty acid transport protein 3

1

6

High-throughput

0.445

High

1392602

S41A3
Solute carrier family 41 member 3

1

2

High-throughput

0.445

High

1461366

BAG5
BAG family molecular chaperone regulator 5

1

10

High-throughput

0.445

High

1491611

PCDGH
Protocadherin gamma-B5

1

6

High-throughput

0.445

High

1491657

PCDG5
Protocadherin gamma-A5

1

6

High-throughput

0.445

High

181746

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.437

High

327517

ZFPL1
Zinc finger protein-like 1

1

4

High-throughput

0.437

High

631047

RAB4A
Ras-related protein Rab-4A

1

20

High-throughput

0.437

High

868805

LEG7
Galectin-7

1

20

High-throughput

0.437

High

956561

RAB2A
Ras-related protein Rab-2A

1

20

High-throughput

0.437

High

1293225

TMM17
Transmembrane protein 17

1

5

High-throughput

0.437

High

1382023

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.437

High

1452738

ELOV5
Very long chain fatty acid elongase 5

1

9

High-throughput

0.437

High

1459485

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

50742

HACL2
2-hydroxyacyl-CoA lyase 2

1

6

High-throughput

0.407

High

761945

HSP74
Heat shock 70 kDa protein 4

1

20

High-throughput

0.407

High

1010133

DLK1
Protein delta homolog 1

1

9

High-throughput

0.407

High

1106152

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

16

High-throughput

0.407

High

1238397

RETST
All-trans-retinol 13,14-reductase

1

9

High-throughput

0.407

High

1328233

JAGN1
Protein jagunal homolog 1

1

3

High-throughput

0.407

High

1393231

TM169
Transmembrane protein 169

1

1

High-throughput

0.407

High

1405928

DNJC7
DnaJ homolog subfamily C member 7

1

16

High-throughput

0.407

High

1436671

ZDH11
Palmitoyltransferase ZDHHC11

1

6

High-throughput

0.407

High

1462290

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.407

High

1380432

TMM54
Transmembrane protein 54

2

0

High-throughput

0.316

High

1460880

FBX2
F-box only protein 2

1

0

High-throughput

0.279

Low

1310149

MGAP
MAX gene-associated protein

1

0

High-throughput

0.269

Low

402441

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.249

Low

1229806

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

844283

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025