HitPredict

Interactor 1: BMP8B (P34820)
Bone morphogenetic protein 8B (BMP-8) (BMP-8B) (Osteogenic protein 2) (OP-2)
Gene: BMP8B

Interactor 2: WFKN2 (Q8TEU8)
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (Growth and differentiation factor-associated serum protein 1) (GASP-1) (hGASP-1) (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein) (WFIKKN-related protein)
Gene: WFIKKN2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21054789
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001501 - skeletal system development GO:0005615 - extracellular space
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 402 Hs			1 576
+	Hs
		520165 BMP4_HUMAN (4-401): 1.33e-117: 349: 29.70		WFKN2_HUMAN (1-576): 0: 590: 100.00
+	Hs
		520084 BMP2_HUMAN (20-401): 1.6e-114: 341: 27.83		WFKN2_HUMAN (1-576): 0: 590: 100.00
+	Hs
		713418 BMP8B_HUMAN (33-402): 9.3e-153: 439: 100.00		WFKN1_HUMAN (30-572): 2.8e-159: 468: 53.95
+	Mm
		139690 GDF8_MOUSE (31-401): 1.92e-86: 269: 24.60		WFKN2_MOUSE (1-576): 0: 584: 91.49
+	Hs
		312863 GDF11_HUMAN (21-401): 1.55e-76: 244: 20.76		WFKN2_HUMAN (1-576): 0: 590: 100.00
+	Hs
		351426 TGFB1_HUMAN (42-401): 7.98e-77: 244: 20.27		WFKN2_HUMAN (1-576): 0: 590: 100.00
+	Hs
		520193 BMP3_HUMAN (6-401): 2.52e-73: 238: 18.57		WFKN2_HUMAN (1-576): 0: 590: 100.00
+	Hs
		520170 BMP4_HUMAN (4-401): 1.33e-117: 349: 29.70		WFKN1_HUMAN (30-572): 2.8e-159: 468: 53.95
+	Hs
		520086 BMP2_HUMAN (20-401): 1.6e-114: 341: 27.83		WFKN1_HUMAN (30-572): 2.8e-159: 468: 53.95
+	Hs
		155768 GDF8_HUMAN (31-401): 1.07e-87: 272: 24.60		WFKN1_HUMAN (30-572): 2.8e-159: 468: 53.95
+	Hs
		312868 GDF11_HUMAN (21-401): 1.55e-76: 244: 20.76		WFKN1_HUMAN (30-572): 2.8e-159: 468: 53.95
+	Hs
		351437 TGFB1_HUMAN (42-401): 7.98e-77: 244: 20.27		WFKN1_HUMAN (30-572): 2.8e-159: 468: 53.95
+	Hs
		520195 BMP3_HUMAN (6-401): 2.52e-73: 238: 18.57		WFKN1_HUMAN (30-572): 2.8e-159: 468: 53.95
+	Hs
		155749 GDF8_HUMAN (31-401): 1.07e-87: 272: 24.60		A4_HUMAN (332-380): 8.75e-14: 76.6: 36.74
+	Hs
		394464 TGFB2_HUMAN (10-401): 6.65e-84: 264: 19.95		A4_HUMAN (332-380): 8.75e-14: 76.6: 36.74
+	Hs
		312840 GDF11_HUMAN (21-401): 1.55e-76: 244: 20.76		A4_HUMAN (332-380): 8.75e-14: 76.6: 36.74
+	Hs
		351214 TGFB1_HUMAN (42-401): 7.98e-77: 244: 20.27		A4_HUMAN (332-380): 8.75e-14: 76.6: 36.74
+	Hs
		255409 TGFB1_HUMAN (42-401): 7.98e-77: 244: 20.27		OBSL1_HUMAN (182-331): 4.57e-10: 64.7: 25.49
+	Hs
		394433 INHBE_HUMAN (29-401): 2.01e-48: 169: 24.15		A4_HUMAN (332-380): 8.75e-14: 76.6: 36.74