HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: C1TC (P11586)
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
Gene: MTHFD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16263121
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 935
+	Hs
		437841 HS90B_HUMAN (19-732): 0: 1059: 86.13		C1TC_HUMAN (1-935): 0: 1571: 100.00
+	Sc
		365613 HSP82_YEAST (16-732): 0: 907: 60.08		C1TM_YEAST (6-935): 0: 1445: 55.67
+	Sc
		450385 HSC82_YEAST (16-732): 0: 902: 59.39		C1TM_YEAST (6-935): 0: 1445: 55.67
+	Sc
		365570 HSP82_YEAST (16-732): 0: 907: 60.08		C1TC_YEAST (4-935): 0: 1413: 56.86
+	Sc
		423507 HSC82_YEAST (16-732): 0: 902: 59.39		C1TC_YEAST (4-935): 0: 1413: 56.86
+	Sc
		366753 HSP82_YEAST (16-732): 0: 907: 60.08		MTD1_YEAST (3-289): 1.33e-75: 252: 20.85
+	Sc
		544265 HSC82_YEAST (16-732): 0: 902: 59.39		MTD1_YEAST (3-289): 1.33e-75: 252: 20.85