HitPredict

Interactor 1: GRK5 (P34947)
G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)
Gene: GRK5

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22952844
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005080 - protein kinase C binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0009966 - regulation of signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Hs			1 247
+	Hs
		683165 GRK5_HUMAN (1-590): 0: 550: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		714508 GRK5_HUMAN (1-590): 0: 550: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646669 GRK5_HUMAN (1-590): 0: 550: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		909855 GRK7_HUMAN (3-546): 3.1e-146: 435: 43.92		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		566346 KPCA_HUMAN (12-509): 5.54e-142: 428: 25.29		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		681770 AKT1_HUMAN (68-517): 2.1e-141: 420: 29.19		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		408587 KPCB_HUMAN (32-505): 1.11e-140: 425: 26.61		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		568616 KAPCA_HUMAN (148-500): 4.14e-142: 417: 28.61		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		681766 AKT1_HUMAN (68-517): 2.1e-141: 420: 29.19		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		904456 KPCE_HUMAN (85-503): 2.08e-136: 416: 30.30		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		683866 GRK4_HUMAN (1-557): 2e-166: 487: 68.04		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		566348 KPCA_HUMAN (12-509): 5.54e-142: 428: 25.29		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		681776 AKT1_HUMAN (68-517): 2.1e-141: 420: 29.19		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		566293 KPCA_HUMAN (12-509): 5.54e-142: 428: 25.29		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		683276 KPCE_HUMAN (85-503): 2.08e-136: 416: 30.30		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		568620 KAPCA_HUMAN (148-500): 4.14e-142: 417: 28.61		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		684231 GRK7_HUMAN (3-546): 3.1e-146: 435: 43.92		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		646812 KPCE_HUMAN (85-503): 2.08e-136: 416: 30.30		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		681682 AKT1_HUMAN (68-517): 2.1e-141: 420: 29.19		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		683974 KPCE_HUMAN (85-503): 2.08e-136: 416: 30.30		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16