Protein: FBX3
F-box only protein 3

Gene: FBX3, FBXO3
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q9UK99

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992381

SKP1
S-phase kinase-associated protein 1

16

5

Small-scale

0.983

High

1112778

CUL1
Cullin-1

8

3

Small-scale

0.966

High

1460971

FBXL2
F-box/LRR-repeat protein 2

3

1

Small-scale

0.827

High

1114615

CUL3
Cullin-3

2

3

High-throughput

0.789

High

243249

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.754

High

647416

IDS
Iduronate 2-sulfatase

3

7

High-throughput

0.667

High

1154957

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.656

High

1460974

ARI1
E3 ubiquitin-protein ligase ARIH1

3

1

High-throughput

0.650

High

984015

RBX1
E3 ubiquitin-protein ligase RBX1

4

0

Small-scale

0.648

High

831621

CCNF
Cyclin-F

1

1

High-throughput

0.618

High

1460970

FBX3
F-box only protein 3

1

1

High-throughput

0.618

High

508808

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.614

High

58750

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

2

5

High-throughput

0.611

High

1067818

EP300
Histone acetyltransferase p300

2

1

Small-scale

0.584

High

1047776

NOTC2
Neurogenic locus notch homolog protein 2

1

1

High-throughput

0.575

High

1115135

CUL4A
Cullin-4A

1

3

High-throughput

0.575

High

1439001

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

0

Small-scale

0.554

High

228930

CF410
Cilia- and flagella-associated protein 410

1

0

Small-scale

0.537

High

1310512

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

692835

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

754603

S10A3
Protein S100-A3

1

0

High-throughput

0.513

High

787720

SPB5
Serpin B5

1

0

High-throughput

0.513

High

902405

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

0

High-throughput

0.513

High

1347890

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

1370453

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

326793

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.489

High

1388953

ARSG
Arylsulfatase G

1

7

High-throughput

0.489

High

157970

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

231171

AIRE
Autoimmune regulator

1

1

Small-scale

0.479

High

462026

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468897

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

639325

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

High-throughput

0.479

High

714504

PML
Protein PML

1

2

Small-scale

0.479

High

888382

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

905268

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

1108264

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1138737

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1224931

TENS2
Tensin-2

1

2

High-throughput

0.479

High

1241841

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1391840

AURKB
Aurora kinase B

1

1

High-throughput

0.479

High

1419323

TRI55
Tripartite motif-containing protein 55

1

1

High-throughput

0.479

High

1432279

HIPK2
Homeodomain-interacting protein kinase 2

1

1

Small-scale

0.479

High

1434190

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1447696

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

1

Small-scale

0.479

High

1459251

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1460415

HERC5
E3 ISG15--protein ligase HERC5

1

1

Small-scale

0.479

High

1460975

DUS10
Dual specificity protein phosphatase 10

1

1

High-throughput

0.479

High

166582

BACH1
Transcription regulator protein BACH1

1

0

Small-scale

0.458

High

316137

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

785519

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

957548

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

1056661

PAX8
Paired box protein Pax-8

1

0

Small-scale

0.458

High

1240719

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1306932

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

1396859

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1420626

IN80B
INO80 complex subunit B

1

0

High-throughput

0.458

High

1435430

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1460282

XPO7
Exportin-7

1

0

High-throughput

0.458

High

245817

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

1

High-throughput

0.445

High

1116355

RAB31
Ras-related protein Rab-31

1

1

High-throughput

0.445

High

1407178

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

1

High-throughput

0.445

High

1438075

RC3H2
Roquin-2

1

1

High-throughput

0.437

High

1460072

ZNHI2
Zinc finger HIT domain-containing protein 2

1

1

High-throughput

0.437

High

573908

CCNB1
G2/mitotic-specific cyclin-B1

1

0

High-throughput

0.426

High

1272590

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.426

High

1396243

TNIP3
TNFAIP3-interacting protein 3

1

0

High-throughput

0.426

High

1428895

PEG3
Paternally-expressed gene 3 protein

1

0

High-throughput

0.426

High

1460972

HBS1L
HBS1-like protein

1

0

High-throughput

0.426

High

586391

ARSB
Arylsulfatase B

1

7

High-throughput

0.407

High

756591

GALNS
N-acetylgalactosamine-6-sulfatase

1

7

High-throughput

0.407

High

907231

SPHM
N-sulphoglucosamine sulphohydrolase

1

7

High-throughput

0.407

High

1398018

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

1120985

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.279

Low

1207490

CAHM4
Calcium homeostasis modulator protein 4

1

0

High-throughput

0.279

Low

1226837

ATG9B
Autophagy-related protein 9B

1

0

High-throughput

0.279

Low

1236049

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

1286482

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

1353678

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

1460973

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.279

Low

167470

WNT9A
Protein Wnt-9a

1

0

High-throughput

0.232

Low

336210

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

0

High-throughput

0.232

Low

516732

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low

651610

IBP4
Insulin-like growth factor-binding protein 4

1

0

High-throughput

0.232

Low

1272078

SYPM
Probable proline--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

1336917

VGLU3
Vesicular glutamate transporter 3

1

0

High-throughput

0.232

Low

1395422

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low

1459913

EGFL7
Epidermal growth factor-like protein 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025