Protein: LETM1
Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1)

Gene: LETM1
Organism: Homo sapiens
Interactions: 207
UniProt ID: O95202

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006816 - calcium ion transport
GO:0006851 - mitochondrial calcium ion transmembrane transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

307311

CP1A1
Cytochrome P450 1A1

3

0

High-throughput

0.638

High

307474

PCDGG
Protocadherin gamma-B4

2

1

High-throughput

0.628

High

307363

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

307359

GRSF1
G-rich sequence factor 1

2

1

High-throughput

0.584

High

262660

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

307301

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.559

High

307373

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

307452

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

307325

3BHS2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

1

0

High-throughput

0.513

High

307349

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.513

High

307380

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

307395

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.513

High

307398

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

307455

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.513

High

307327

CALR
Calreticulin

1

0

High-throughput

0.493

High

50885

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

1

High-throughput

0.489

High

257866

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.489

High

307306

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.489

High

307308

FRIL
Ferritin light chain

1

2

High-throughput

0.489

High

307328

CLIP1
CAP-Gly domain-containing linker protein 1

1

1

High-throughput

0.489

High

307335

PEX19
Peroxisomal biogenesis factor 19

1

1

High-throughput

0.489

High

307374

RTN1
Reticulon-1

1

4

High-throughput

0.489

High

307412

OPTN
Optineurin

1

1

High-throughput

0.489

High

307456

RTN4
Reticulon-4

1

4

High-throughput

0.489

High

264803

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

269960

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

307334

GRP75
Stress-70 protein, mitochondrial

1

2

High-throughput

0.479

High

307339

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

307358

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

307360

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

307364

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

307385

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

307391

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

307399

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

307408

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

307409

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

307411

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

307413

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

307422

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

307424

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

307425

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

307438

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

High-throughput

0.479

High

307440

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

307445

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

307446

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

307461

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

307466

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

307469

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

307482

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

234168

PEPL
Periplakin

1

1

High-throughput

0.470

High

59074

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

63266

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.458

High

116948

SGK1
Serine/threonine-protein kinase Sgk1

1

0

High-throughput

0.458

High

130385

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

172954

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

203846

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

258381

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

276769

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

307302

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

307304

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

307313

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

307314

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

307316

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

307318

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

307333

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

307336

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

307337

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

307338

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

307341

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

307350

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

307352

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

307354

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

307355

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

307362

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

307368

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

307369

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

307377

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

307384

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

307390

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

307396

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

307402

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.458

High

307405

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

307410

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

307414

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

307415

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

307416

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

307417

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

307418

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

307420

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

307423

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

307426

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

307427

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

307428

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

307429

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

307430

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

307431

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

307432

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

307433

TR61B
tRNA

1

0

High-throughput

0.458

High

307435

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

307436

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

307439

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

307443

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.458

High

307444

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

307447

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

307451

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

307453

NGRN
Neugrin

1

0

High-throughput

0.458

High

307459

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.458

High

307460

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

307462

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

307463

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

307468

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

307476

BCS1
Mitochondrial chaperone BCS1

1

0

Small-scale

0.458

High

307479

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

307310

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.437

High

307319

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

307322

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.437

High

307326

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

307345

RHOA
Transforming protein RhoA

1

1

High-throughput

0.437

High

307351

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.437

High

307353

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

307356

QOR
Quinone oxidoreductase

1

1

High-throughput

0.437

High

307357

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

307365

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

307389

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

307407

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.437

High

307457

LATS2
Serine/threonine-protein kinase LATS2

1

1

High-throughput

0.437

High

307472

UBQL2
Ubiquilin-2

1

1

High-throughput

0.437

High

307473

UBQL1
Ubiquilin-1

1

1

High-throughput

0.437

High

307315

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

307378

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

56582

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.407

High

92753

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

307312

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

307307

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

307403

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.328

High

307421

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

0

High-throughput

0.328

High

307332

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.316

High

307375

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

307324

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.299

High

63025

LR14B
Leucine-rich repeat-containing protein 14B

1

0

High-throughput

0.279

Low

173409

RER1
Protein RER1

1

0

High-throughput

0.279

Low

197157

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.279

Low

263896

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

307299

CEP43
Centrosomal protein 43

1

0

High-throughput

0.279

Low

307300

SNP29
Synaptosomal-associated protein 29

1

0

High-throughput

0.279

Low

307303

DNAL4
Dynein axonemal light chain 4

1

0

High-throughput

0.279

Low

307305

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.279

Low

307321

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.279

Low

307323

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.279

Low

307330

MYH9
Myosin-9

1

0

High-throughput

0.279

Low

307331

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.279

Low

307340

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.279

Low

307344

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.279

Low

307347

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.279

Low

307366

MLC1
Membrane protein MLC1

1

0

High-throughput

0.279

Low

307370

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.279

Low

307371

CART

1

0

High-throughput

0.279

Low

307372

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.279

Low

307376

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

307379

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.279

Low

307381

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.279

Low

307382

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.279

Low

307387

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

307388

RN19B
E3 ubiquitin-protein ligase RNF19B

1

0

High-throughput

0.279

Low

307392

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

307394

MYLK4
Myosin light chain kinase family member 4

1

0

High-throughput

0.279

Low

307397

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

307400

O2T10
Olfactory receptor 2T10

1

0

High-throughput

0.279

Low

307401

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.279

Low

307404

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

High-throughput

0.279

Low

307434

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

307441

F234A
Protein FAM234A

1

0

High-throughput

0.279

Low

307442

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

307449

GSX1
GS homeobox 1

1

0

High-throughput

0.279

Low

307454

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.279

Low

307458

CENPM
Centromere protein M

1

0

High-throughput

0.279

Low

307465

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

307471

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.279

Low

307477

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

307478

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.279

Low

307483

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

174505

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

100335

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

307309

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

307317

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

307320

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

307329

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

307342

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.249

Low

307343

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

307346

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.249

Low

307348

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

307361

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

307367

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

307383

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

307386

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

307393

CLC14
C-type lectin domain family 14 member A

1

0

Small-scale

0.249

Low

307406

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.249

Low

307437

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.249

Low

307448

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

307450

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.249

Low

307464

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

307467

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

307470

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

307475

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

307480

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.249

Low

307481

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

307419

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024