HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: CBX2 (Q14781)
Chromobox protein homolog 2
Gene: CBX2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	24457600, 27705803, 33961781, 37014752, 19636380, 22325352, 24981860, 21282530, 34316702, 20601937
Identification Methods	affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 326 Hs			1 532
+	Mm
		639466 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84
+	Hs
		718398 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00
+	Hs
		123193 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Mm
		620782 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		CBX2_MOUSE (1-532): 1.26e-145: 430: 81.84
+	Mm
		223225 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		CBX4_MOUSE (3-522): 1.1e-116: 357: 22.28
+	Hs
		123194 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Dr
		1193374 BMI1A_DANRE (1-326): 9.35e-128: 369: 81.29		Q804D1_DANRE (3-521): 3.29e-99: 310: 24.04
+	Dr
		1186372 BMI1B_DANRE (1-322): 4e-124: 360: 77.23		Q804D1_DANRE (3-521): 3.29e-99: 310: 24.04
+	Hs
		718131 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		MPP8_HUMAN (7-397): 6.88e-47: 177: 17.54
+	Hs
		315976 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Hs
		718213 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX8_HUMAN (3-238): 1.39e-35: 139: 29.39
+	Hs
		717776 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Mm
		639481 BMI1_MOUSE (1-326): 2.15e-150: 426: 96.93		CBX8_MOUSE (3-238): 1.64e-38: 146: 31.75
+	Hs
		327830 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX7_HUMAN (3-210): 1.4e-35: 135: 27.98
+	Hs
		717529 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		CBX5_HUMAN (12-152): 1.24e-35: 133: 24.66
+	Hs
		315977 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Hs
		718431 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX8_HUMAN (3-238): 1.39e-35: 139: 29.39
+	Hs
		718395 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		327831 PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36		CBX7_HUMAN (3-210): 1.4e-35: 135: 27.98
+	Mm
		620791 PCGF2_MOUSE (1-320): 5.49e-113: 332: 61.06		CBX7_MOUSE (3-117): 1.22e-29: 115: 42.24