Protein: CLOCK
Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)

Gene: CLOCK
Organism: Homo sapiens
Interactions: 88
UniProt ID: O15516

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

132684

BMAL1
Basic helix-loop-helix ARNT-like protein 1

15

19

Small-scale

0.983

High

192948

BMAL2
Basic helix-loop-helix ARNT-like protein 2

6

20

Small-scale

0.946

High

192957

NPAS2
Neuronal PAS domain-containing protein 2

2

20

High-throughput

0.793

High

192960

CIPC
CLOCK-interacting pacemaker

4

4

High-throughput

0.695

High

192890

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

3

2

High-throughput

0.667

High

192947

TEKT4
Tektin-4

3

0

High-throughput

0.638

High

192925

CRY1
Cryptochrome-1

3

15

Small-scale

0.629

High

176104

PER2
Period circadian protein homolog 2

1

19

High-throughput

0.621

High

192899

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

20

Small-scale

0.621

High

192961

BHE41
Class E basic helix-loop-helix protein 41

1

19

High-throughput

0.621

High

192897

PDE6A
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

1

2

High-throughput

0.618

High

192901

PDE6B
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

1

2

High-throughput

0.618

High

192907

MAX
Protein max

1

8

High-throughput

0.618

High

192966

EXOC1
Exocyst complex component 1

2

0

High-throughput

0.602

High

192941

POC1A
POC1 centriolar protein homolog A

2

8

High-throughput

0.601

High

192889

CLOCK
Circadian locomoter output cycles protein kaput

1

20

Small-scale

0.590

High

192927

CRY2
Cryptochrome-2

2

15

Small-scale

0.586

High

192914

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.586

High

192908

RHOA
Transforming protein RhoA

1

2

Small-scale

0.561

High

192952

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

10

Small-scale

0.561

High

192900

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

4

High-throughput

0.552

High

192902

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

6

High-throughput

0.552

High

192905

KC1E
Casein kinase I isoform epsilon

1

11

High-throughput

0.552

High

192906

RORG
Nuclear receptor ROR-gamma

1

20

High-throughput

0.552

High

192909

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

High-throughput

0.552

High

192910

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

6

High-throughput

0.552

High

192912

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.552

High

192923

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

20

High-throughput

0.552

High

192931

Q58EY0
RAR related orphan receptor B isoform 1

1

20

High-throughput

0.552

High

192903

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

192904

PRC2A
Protein PRRC2A

1

4

High-throughput

0.536

High

192921

PUM1
Pumilio homolog 1

1

1

High-throughput

0.536

High

192956

CCNL2
Cyclin-L2

1

2

High-throughput

0.536

High

192895

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.527

High

192898

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.527

High

192896

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

192913

COG7
Conserved oligomeric Golgi complex subunit 7

1

0

High-throughput

0.513

High

192937

KHDC4
KH homology domain-containing protein 4

1

0

High-throughput

0.513

High

192942

TDRD9
ATP-dependent RNA helicase TDRD9

1

0

High-throughput

0.513

High

192943

NEUA
N-acylneuraminate cytidylyltransferase

1

0

High-throughput

0.513

High

192918

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

192950

KAT2B
Histone acetyltransferase KAT2B

1

12

Small-scale

0.501

High

192939

CIART
Circadian-associated transcriptional repressor

1

1

Small-scale

0.500

High

192919

DBP
D site-binding protein

1

11

High-throughput

0.481

High

192922

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

1

High-throughput

0.481

High

192926

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

1

High-throughput

0.481

High

128353

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

High-throughput

0.479

High

192891

MS18B
Protein Mis18-beta

1

1

High-throughput

0.479

High

192892

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.479

High

192893

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.479

High

192894

TFPT
TCF3 fusion partner

1

1

High-throughput

0.479

High

192911

H4
Histone H4

1

6

High-throughput

0.479

High

192916

TLE2
Transducin-like enhancer protein 2

1

13

High-throughput

0.479

High

192917

TLE3
Transducin-like enhancer protein 3

1

12

High-throughput

0.479

High

192920

GIT2
ARF GTPase-activating protein GIT2

1

3

High-throughput

0.479

High

192924

RABE1
Rab GTPase-binding effector protein 1

1

9

High-throughput

0.479

High

192928

GRAP1
GRIP1-associated protein 1

1

11

High-throughput

0.479

High

192929

EIPR1
EARP and GARP complex-interacting protein 1

1

7

High-throughput

0.479

High

192930

CCD93
Coiled-coil domain-containing protein 93

1

1

High-throughput

0.479

High

192932

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

1

High-throughput

0.479

High

192934

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.479

High

192935

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.479

High

192936

HAUS6
HAUS augmin-like complex subunit 6

1

2

High-throughput

0.479

High

192946

CCHCR
Coiled-coil alpha-helical rod protein 1

1

9

High-throughput

0.479

High

192949

CBP
CREB-binding protein

1

20

Small-scale

0.479

High

192951

PF21A
PHD finger protein 21A

1

8

High-throughput

0.479

High

192953

THA11
THAP domain-containing protein 11

1

1

High-throughput

0.479

High

192955

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.479

High

192959

NUF2
Kinetochore protein Nuf2

1

2

High-throughput

0.479

High

192965

HM20A
High mobility group protein 20A

1

17

High-throughput

0.479

High

192968

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

1

High-throughput

0.479

High

192969

RABX5
Rab5 GDP/GTP exchange factor

1

4

High-throughput

0.479

High

192970

RCOR1
REST corepressor 1

1

9

High-throughput

0.479

High

192971

CHIP
E3 ubiquitin-protein ligase CHIP

1

15

Small-scale

0.479

High

192958

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

192962

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.458

High

192915

KMT2A
Histone-lysine N-methyltransferase 2A

1

8

Small-scale

0.457

High

192940

STAG2
Cohesin subunit SA-2

1

1

Small-scale

0.445

High

192967

DEC1
Deleted in esophageal cancer 1

1

2

High-throughput

0.439

High

85218

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

1

High-throughput

0.437

High

192933

PHLB3
Pleckstrin homology-like domain family B member 3

1

4

High-throughput

0.437

High

192938

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

10

High-throughput

0.437

High

192944

GOGA5
Golgin subfamily A member 5

1

13

High-throughput

0.437

High

192945

POC1B
POC1 centriolar protein homolog B

1

8

High-throughput

0.437

High

192954

VPS50
Syndetin

1

1

High-throughput

0.437

High

192963

NCK5L
Nck-associated protein 5-like

1

1

High-throughput

0.437

High

192964

TUFT1
Tuftelin

1

1

High-throughput

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025