HitPredict

Interactor 1: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Interactor 2: RN114 (Q9Y508)
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)
Gene: RNF114

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	22493164
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	zf-C3HC4_2~zf_C2HC_14
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 228
+	Hs
		717765 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		TRI26_HUMAN (15-162): 1.14e-29: 117: 16.88
+	Hs
		717818 BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00		TRI25_HUMAN (18-176): 2.8e-22: 96.4: 17.84
+	Hs
		1290199 PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33		RN125_HUMAN (2-227): 2.29e-48: 160: 30.84
+	Hs
		585033 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		RN125_HUMAN (2-227): 2.29e-48: 160: 30.84
+	Hs
		1019293 TRI26_HUMAN (5-210): 1e-49: 175: 16.59		TRI26_HUMAN (15-162): 1.14e-29: 117: 16.88
+	Hs
		1019359 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		TRI26_HUMAN (15-162): 1.14e-29: 117: 16.88
+	Hs
		584870 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		RO52_HUMAN (15-134): 8.35e-26: 106: 18.98
+	Mm
		1112402 RO52_MOUSE (3-192): 1.62e-52: 181: 17.28		Q3U7K7_MOUSE (19-135): 2.03e-24: 101: 15.67
+	Hs
		585075 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		TRI39_HUMAN (1-150): 1.11e-23: 100: 19.28
+	Hs
		585058 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		TRIM5_HUMAN (16-222): 1.94e-23: 99.6: 17.11
+	Hs
		1115440 TRI60_HUMAN (9-196): 1.12e-52: 181: 15.46		LNX1_HUMAN (20-191): 1.01e-22: 98: 16.23
+	Hs
		585019 RO52_HUMAN (5-198): 5.75e-52: 180: 18.78		LNX1_HUMAN (20-191): 1.01e-22: 98: 16.23
+	Hs
		1223387 TRI22_HUMAN (1-198): 2.92e-50: 175: 14.56		TRI22_HUMAN (22-134): 2.94e-24: 101: 19.12
+	Hs
		1318709 TRIM6_HUMAN (5-189): 2.83e-49: 173: 16.67		TRIM5_HUMAN (16-222): 1.94e-23: 99.6: 17.11
+	Hs
		1318711 TRIM5_HUMAN (9-190): 3.01e-48: 170: 14.89		TRIM5_HUMAN (16-222): 1.94e-23: 99.6: 17.11
+	Hs
		1318708 TRIM6_HUMAN (5-189): 2.83e-49: 173: 16.67		TRIM6_HUMAN (16-134): 2.74e-22: 96.1: 18.31
+	Hs
		1052744 RING2_HUMAN (7-227): 8.37e-50: 170: 16.61		TRI25_HUMAN (18-176): 2.8e-22: 96.4: 17.84