HitPredict

Interactor 1: NOS2 (P35228)
Nitric oxide synthase, inducible (EC 1.14.13.39) (Hepatocyte NOS) (HEP-NOS) (Inducible NO synthase) (Inducible NOS) (iNOS) (NOS type II) (Peptidyl-cysteine S-nitrosylase NOS2)
Gene: NOS2

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

The method score is based on:

Property	Details
Experiments	18668140, 17720813, 11438703
Identification Methods	anti tag coimmunoprecipitation, electrophoretic mobility supershift assay
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006954 - inflammatory response and 5 others more... GO:0032755 - positive regulation of interleukin-6 production GO:0032757 - positive regulation of interleukin-8 production GO:0042177 - negative regulation of protein catabolic process GO:0042803 - protein homodimerization activity GO:0071222 - cellular response to lipopolysaccharide
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	1153
Hs

1	551

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024