HitPredict

Interactor 1: PTN11 (P35235)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
Gene: Ptpn11

Interactor 2: IL6RB (Q00560)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: Il6st

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	9507023, 7559603
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 593 Mm			1 917
+	Hs
		770199 PTN11_HUMAN (1-593): 0: 606: 99.49		IL6RB_HUMAN (1-917): 0: 587: 76.82
+	Hs
		665811 PTN6_HUMAN (6-593): 0: 540: 54.79		IL6RB_HUMAN (1-917): 0: 587: 76.82
+	Hs
		986020 PTN11_HUMAN (1-593): 0: 606: 99.49		CSF3R_HUMAN (5-794): 1.53e-99: 332: 24.82
+	Hs
		560475 PTN11_HUMAN (1-593): 0: 606: 99.49		PRLR_HUMAN (124-331): 1.44e-44: 173: 25.46
+	Mm
		719289 PTN11_MOUSE (1-593): 0: 605: 100.00		LEPR_MOUSE (4-790): 1.98e-17: 89.6: 14.59
+	Hs
		817317 PTN11_HUMAN (1-593): 0: 606: 99.49		LEPR_HUMAN (293-790): 1.34e-14: 80.8: 14.21
+	Hs
		265768 PTPRS_HUMAN (33-522): 2.56e-118: 388: 26.84		CRLF1_HUMAN (31-393): 1.52e-84: 279: 24.93
+	Hs
		616971 PTPRS_HUMAN (33-522): 2.56e-118: 388: 26.84		PTPRD_HUMAN (1-846): 3.05e-76: 275: 12.82
+	Hs
		616939 PTPRD_HUMAN (36-522): 7.52e-116: 381: 27.00		PTPRD_HUMAN (1-846): 3.05e-76: 275: 12.82
+	Hs
		665815 PTN6_HUMAN (6-593): 0: 540: 54.79		LIFR_HUMAN (127-769): 2.32e-25: 115: 13.85
+	Hs
		489957 PTPRS_HUMAN (33-522): 2.56e-118: 388: 26.84		PTPRF_HUMAN (109-917): 7.48e-64: 237: 11.62
+	Hs
		489886 PTPRF_HUMAN (33-522): 1.43e-113: 374: 26.04		PTPRF_HUMAN (109-917): 7.48e-64: 237: 11.62
+	Hs
		490002 PTPR2_HUMAN (135-531): 8.99e-113: 362: 30.15		PTPRF_HUMAN (109-917): 7.48e-64: 237: 11.62
+	Hs
		616914 PTPRB_HUMAN (135-554): 5.13e-119: 390: 27.19		CNTN1_HUMAN (27-900): 1.04e-41: 167: 9.12
+	Hs
		616916 PTPRB_HUMAN (135-554): 5.13e-119: 390: 27.19		PTPRS_HUMAN (424-916): 8.31e-17: 88.2: 8.21
+	Hs
		1031977 PTPRS_HUMAN (33-522): 2.56e-118: 388: 26.84		PTPRS_HUMAN (424-916): 8.31e-17: 88.2: 8.21
+	Hs
		616927 PTPRB_HUMAN (135-554): 5.13e-119: 390: 27.19		NRCAM_HUMAN (24-902): 6.01e-09: 62.4: 9.19
+	Hs
		817318 PTPRJ_HUMAN (180-528): 2.11e-110: 361: 31.81		LEPR_HUMAN (293-790): 1.34e-14: 80.8: 14.21