HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	24366813, 25796446, 27684187, 30472188, 26933062, 38280479, 24255178, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0072091 - regulation of stem cell proliferation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 504
+	Hs
		125188 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54
+	Hs
		719588 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73
+	Hs
		547209 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42
+	Hs
		546968 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		640152 MOES_HUMAN (19-595): 5.97e-146: 435: 44.44		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		546967 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26
+	Hs
		505580 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		1336123 E41L3_HUMAN (14-484): 8.79e-113: 363: 21.04		SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05
+	Hs
		204630 E41L2_HUMAN (11-519): 9e-113: 361: 19.70		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		719609 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		547208 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		719536 MERL_HUMAN (1-595): 1.12e-172: 504: 100.00		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27
+	Hs
		505678 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Dm
		1098312 MERH_DROME (12-595): 1.63e-133: 405: 45.35		KIBRA_DROME (169-320): 3.18e-32: 133: 28.29
+	Dm
		2636 MERH_DROME (12-595): 1.63e-133: 405: 45.35		A0A0B4LH59_DROME (169-320): 3.18e-32: 133: 28.29
+	Hs
		505658 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27
+	Hs
		1220100 E41L3_HUMAN (14-484): 8.79e-113: 363: 21.04		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27
+	Hs
		204697 E41L2_HUMAN (11-519): 9e-113: 361: 19.70		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27
+	Hs
		299270 FARP2_HUMAN (3-537): 6.42e-112: 360: 17.89		KIBRA_HUMAN (167-309): 1.03e-35: 144: 27.27