Protein: MDHM
Malate dehydrogenase, mitochondrial (EC 1.1.1.37)

Gene: MDHM, MDH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 116
UniProt ID: P17505

Gene Ontology (top 5):
GO:0003729 - mRNA binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006099 - tricarboxylic acid cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

604923

MDHP
Malate dehydrogenase, peroxisomal

2

14

Small-scale

0.754

High

510161

HSP77
Import motor subunit, mitochondrial

4

10

Small-scale

0.672

High

604895

ACON
Aconitate hydratase, mitochondrial

3

4

Small-scale

0.640

High

604939

LONM
Lon protease homolog, mitochondrial

3

12

Small-scale

0.640

High

604962

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

3

3

Small-scale

0.640

High

604934

HSP78
Heat shock protein 78, mitochondrial

3

1

Small-scale

0.633

High

367355

CISY1
Citrate synthase, mitochondrial

2

7

Small-scale

0.624

High

604901

MDHC
Malate dehydrogenase, cytoplasmic

1

14

Small-scale

0.618

High

604938

MIC60
MICOS complex subunit MIC60

3

0

Small-scale

0.613

High

456325

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

2

1

Small-scale

0.584

High

594871

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

2

5

High-throughput

0.584

High

604897

HSP60
Heat shock protein 60, mitochondrial

2

4

Small-scale

0.584

High

604912

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

2

4

High-throughput

0.584

High

604918

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

2

7

Small-scale

0.584

High

604921

HS104
Heat shock protein 104

2

2

Small-scale

0.584

High

604932

PREP
Presequence protease, mitochondrial

2

5

Small-scale

0.584

High

475155

CISY2
Citrate synthase, peroxisomal

1

7

Small-scale

0.561

High

439081

ILV5
Ketol-acid reductoisomerase, mitochondrial

2

0

Small-scale

0.559

High

452625

ADH3
Alcohol dehydrogenase 3, mitochondrial

2

0

Small-scale

0.559

High

604955

SSB2
Ribosome-associated molecular chaperone SSB2

2

8

High-throughput

0.552

High

604903

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.536

High

604910

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

2

High-throughput

0.536

High

604913

CDC20
APC/C activator protein CDC20

1

4

High-throughput

0.536

High

604925

APE2
Aminopeptidase 2, mitochondrial

1

2

High-throughput

0.536

High

604928

PP12
Serine/threonine-protein phosphatase PP1-2

1

3

High-throughput

0.536

High

604929

FIMB
Fimbrin

1

3

High-throughput

0.536

High

604930

RAD54
DNA repair and recombination protein RAD54

1

4

High-throughput

0.536

High

604942

ATR
Serine/threonine-protein kinase MEC1

1

3

High-throughput

0.536

High

604946

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.536

High

604956

RAD26
DNA repair and recombination protein RAD26

1

4

High-throughput

0.536

High

604968

RBG2
Ribosome-interacting GTPase 2

1

4

High-throughput

0.536

High

366638

ARGI
Arginase

1

0

High-throughput

0.513

High

604920

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

604936

SLD2
DNA replication regulator SLD2

1

0

High-throughput

0.513

High

604957

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.513

High

604979

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

557558

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

Small-scale

0.501

High

525854

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.500

High

459008

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.489

High

604896

PRP6
Pre-mRNA-splicing factor 6

1

2

High-throughput

0.489

High

604982

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

7

High-throughput

0.489

High

517884

SSBP1
Single-stranded nucleic acid-binding protein

1

0

Small-scale

0.480

High

366915

ATPB
ATP synthase subunit beta, mitochondrial

1

6

High-throughput

0.479

High

392184

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.479

High

399340

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

4

Small-scale

0.479

High

399790

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

439556

LEU1
2-isopropylmalate synthase

1

2

Small-scale

0.479

High

453242

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

6

Small-scale

0.479

High

484715

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

6

Small-scale

0.479

High

522341

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.479

High

604898

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

7

Small-scale

0.479

High

604899

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

Small-scale

0.479

High

604900

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

3

High-throughput

0.479

High

604902

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

604904

UBA1
Ubiquitin-activating enzyme E1 1

1

2

Small-scale

0.479

High

604905

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.479

High

604911

CDC48
Cell division control protein 48

1

8

High-throughput

0.479

High

604914

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

3

High-throughput

0.479

High

604916

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

8

High-throughput

0.479

High

604926

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

High-throughput

0.479

High

604927

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

2

High-throughput

0.479

High

604931

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

1

High-throughput

0.479

High

604935

PRX1
Peroxiredoxin PRX1, mitochondrial

1

7

Small-scale

0.479

High

604940

ETR1
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

1

2

High-throughput

0.479

High

604944

GRPE
GrpE protein homolog, mitochondrial

1

1

High-throughput

0.479

High

604949

FHP
Flavohemoprotein

1

1

Small-scale

0.479

High

604952

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

3

High-throughput

0.479

High

604960

ETFB
Probable electron transfer flavoprotein subunit beta

1

3

High-throughput

0.479

High

604965

LYS4
Homoaconitase, mitochondrial

1

4

High-throughput

0.479

High

604966

ALAT1
Alanine aminotransferase, mitochondrial

1

3

High-throughput

0.479

High

604967

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

604970

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

604971

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

5

Small-scale

0.479

High

604973

ATN2
Sodium/potassium exporting P-type ATPase 2

1

3

Small-scale

0.479

High

604974

CLU
Clustered mitochondria protein 1

1

1

Small-scale

0.479

High

604976

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

10

High-throughput

0.479

High

604980

ETFD
Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

1

High-throughput

0.479

High

360941

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

Small-scale

0.458

High

432284

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

Small-scale

0.458

High

604908

PRTD
Saccharolysin

1

0

High-throughput

0.458

High

604909

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.458

High

604915

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.458

High

604917

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.458

High

604922

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

604924

BIOB
Biotin synthase, mitochondrial

1

0

Small-scale

0.458

High

604933

RM06
Large ribosomal subunit protein uL6m

1

0

High-throughput

0.458

High

604937

RM38
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.458

High

604947

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

604948

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

604950

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

604953

AIM9
Altered inheritance of mitochondria protein 9, mitochondrial

1

0

High-throughput

0.458

High

604954

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

604958

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

604961

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

Small-scale

0.458

High

604963

DLD2
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2

1

0

High-throughput

0.458

High

604964

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

604972

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

0

High-throughput

0.458

High

604975

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

604981

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

364913

KPYK1
Pyruvate kinase 1

1

2

High-throughput

0.445

High

543733

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

564776

ATN1
Sodium/potassium exporting P-type ATPase 1

1

3

Small-scale

0.437

High

604906

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

604907

BUD31
Pre-mRNA-splicing factor BUD31

1

1

Small-scale

0.437

High

604919

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

604941

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.437

High

604943

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

604977

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

604983

ATN5
Sodium/potassium exporting P-type ATPase 5

1

3

Small-scale

0.437

High

394204

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

604959

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

449310

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

High-throughput

0.279

Low

604951

GIP2
GLC7-interacting protein 2

1

0

High-throughput

0.279

Low

604969

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.279

Low

604978

YD306
F-box protein YDR306C

1

0

High-throughput

0.279

Low

604945

YGP1
Protein YGP1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025