HitPredict

Interactor 1: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Interactor 2: LIPA1 (Q13136)
Liprin-alpha-1 (LAR-interacting protein 1) (LIP-1) (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1)
Gene: PPFIA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 1202
+	Hs
		1025348 E41L5_HUMAN (2-595): 6.77e-134: 410: 18.38		LIPA1_HUMAN (1-1202): 8.2e-166: 526: 100.00
+	Hs
		1025349 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		LIPA1_HUMAN (1-1202): 8.2e-166: 526: 100.00
+	Hs
		640054 MOES_HUMAN (19-595): 5.97e-146: 435: 44.44		MYH9_HUMAN (177-857): 4.68e-24: 112: 15.37
+	Hs
		547120 EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20		LIPB1_HUMAN (407-643): 5.73e-09: 62.8: 11.62
+	Hs
		505568 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		MYH9_HUMAN (177-857): 4.68e-24: 112: 15.37
+	Dm
		114421 MERH_DROME (12-595): 1.63e-133: 405: 45.35		M9PCD4_DROME (3-277): 4.35e-10: 66.3: 12.59
+	Dm
		1098330 MERH_DROME (12-595): 1.63e-133: 405: 45.35		Q9VM93_DROME (3-277): 1.13e-09: 65.1: 12.59
+	Hs
		505542 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		MYH1_HUMAN (461-886): 1.18e-11: 71.7: 7.44
+	Hs
		505569 EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73		MYH10_HUMAN (320-813): 7.13e-10: 66: 11.29
+	Hs
		1331065 E41L1_HUMAN (1-535): 3.42e-120: 378: 21.61		MYH4_HUMAN (461-886): 4.97e-11: 69.7: 7.67
+	Hs
		1203021 E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46		LIPB1_HUMAN (407-643): 5.73e-09: 62.8: 11.62