HitPredict

Interactor 1: CBX2 (P30658)
Chromobox protein homolog 2 (M33) (Modifier 3 protein)
Gene: CBX2

Interactor 2: RYBP (Q8CCI5)
RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor)
Gene: RYBP

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	0.60	0.527

Property	Details
Experiments	10369680
Identification Methods	pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0031519 - PcG protein complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 519 Mm			1 228
+	Hs
		1132216 CBX2_HUMAN (1-519): 2.31e-135: 404: 82.40		RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12
+	Hs
		1132213 CBX2_HUMAN (1-519): 2.31e-135: 404: 82.40		YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33
+	Hs
		129770 CBX4_HUMAN (3-509): 3e-100: 314: 22.20		RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12
+	Hs
		129765 CBX4_HUMAN (3-509): 3e-100: 314: 22.20		YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33
+	Hs
		1326095 CBX8_HUMAN (3-321): 7.3e-49: 174: 22.84		RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12
+	Hs
		1314055 CBX8_HUMAN (3-321): 7.3e-49: 174: 22.84		YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33
+	Hs
		1014157 CBX1_HUMAN (18-168): 2.22e-40: 145: 22.52		RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12
+	Hs
		1097418 CBX3_HUMAN (10-168): 5.67e-39: 142: 20.76		RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12
+	Hs
		338900 CBX6_HUMAN (3-357): 2.5e-34: 135: 24.05		RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12
+	Hs
		1014155 CBX1_HUMAN (18-168): 2.22e-40: 145: 22.52		YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33
+	Hs
		1097411 CBX3_HUMAN (10-168): 5.67e-39: 142: 20.76		YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33
+	Hs
		338896 CBX6_HUMAN (3-357): 2.5e-34: 135: 24.05		YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33