Protein: YAF2
YY1-associated factor 2

Gene: YAF2
Organism: Homo sapiens
Interactions: 220
UniProt ID: Q8IY57

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1055823

RING1
E3 ubiquitin-protein ligase RING1

11

20

High-throughput

0.981

High

1314041

RING2
E3 ubiquitin-protein ligase RING2

12

20

Small-scale

0.980

High

765690

BMI1
Polycomb complex protein BMI-1

8

20

Small-scale

0.968

High

1286244

PCGF5
Polycomb group RING finger protein 5

8

20

High-throughput

0.966

High

1314044

PCGF1
Polycomb group RING finger protein 1

7

20

Small-scale

0.965

High

766102

PCGF2
Polycomb group RING finger protein 2

7

20

Small-scale

0.960

High

1185921

PCGF3
Polycomb group RING finger protein 3

6

20

High-throughput

0.945

High

1314048

PCGF6
Polycomb group RING finger protein 6

6

20

High-throughput

0.945

High

1314018

RYBP
RING1 and YY1-binding protein

3

3

High-throughput

0.861

High

507268

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

4

High-throughput

0.811

High

625481

CSK22
Casein kinase II subunit alpha'

11

4

High-throughput

0.758

High

1250615

BCOR
BCL-6 corepressor

9

7

Small-scale

0.754

High

997839

CSK21
Casein kinase II subunit alpha

8

4

High-throughput

0.752

High

1314022

KDM2B
Lysine-specific demethylase 2B

7

4

High-throughput

0.745

High

1310082

MGAP
MAX gene-associated protein

6

3

High-throughput

0.733

High

995125

CSK2B
Casein kinase II subunit beta

6

1

High-throughput

0.732

High

1204620

BCORL
BCL-6 corepressor-like protein 1

6

6

High-throughput

0.732

High

1314034

LMBL2
Lethal(3)malignant brain tumor-like protein 2

6

4

High-throughput

0.732

High

1314027

AUTS2
Autism susceptibility gene 2 protein

5

7

Small-scale

0.720

High

282748

E2F6
Transcription factor E2F6

5

4

High-throughput

0.718

High

965080

WDR5
WD repeat-containing protein 5

5

2

High-throughput

0.714

High

1122844

TFDP1
Transcription factor Dp-1

4

2

High-throughput

0.699

High

964670

DCAF7
DDB1- and CUL4-associated factor 7

4

7

High-throughput

0.697

High

1314033

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

2

High-throughput

0.694

High

1097411

CBX3
Chromobox protein homolog 3

4

12

Small-scale

0.686

High

1154870

NEDD8
Ubiquitin-like protein NEDD8

1

2

Small-scale

0.681

High

1314053

FBRS
Probable fibrosin-1

6

6

High-throughput

0.668

High

959615

MAX
Protein max

3

4

Small-scale

0.667

High

1202202

DCAF6
DDB1- and CUL4-associated factor 6

3

3

High-throughput

0.667

High

1028275

MDM2
E3 ubiquitin-protein ligase Mdm2

3

1

High-throughput

0.662

High

992250

SKP1
S-phase kinase-associated protein 1

3

2

High-throughput

0.656

High

508259

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.647

High

1314016

YAF2
YY1-associated factor 2

1

3

Small-scale

0.647

High

1314057

FBSL
Fibrosin-1-like protein

4

6

High-throughput

0.636

High

1314019

PAF1
RNA polymerase II-associated factor 1 homolog

3

0

High-throughput

0.634

High

1314076

FBX7
F-box only protein 7

3

0

High-throughput

0.634

High

384174

CO1A1
Collagen alpha-1(I) chain

2

1

High-throughput

0.628

High

1040735

ENL
Protein ENL

2

2

High-throughput

0.628

High

1089230

TRI26
Tripartite motif-containing protein 26

2

2

High-throughput

0.628

High

1195569

ARI4B
AT-rich interactive domain-containing protein 4B

2

1

High-throughput

0.628

High

1250446

MCAF1
Activating transcription factor 7-interacting protein 1

2

2

High-throughput

0.628

High

1314026

MORC4
MORC family CW-type zinc finger protein 4

2

1

High-throughput

0.628

High

1314056

CHD8
Chromodomain-helicase-DNA-binding protein 8

2

3

High-throughput

0.628

High

1314031

RIT1
GTP-binding protein Rit1

1

10

High-throughput

0.618

High

591724

H2AX
Histone H2AX

1

2

High-throughput

0.618

High

685640

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.618

High

931683

RD23B
UV excision repair protein RAD23 homolog B

1

2

High-throughput

0.618

High

1029514

SRSF2
Serine/arginine-rich splicing factor 2

1

2

High-throughput

0.618

High

1033062

EWS
RNA-binding protein EWS

1

3

High-throughput

0.618

High

1147204

ELOB
Elongin-B

1

1

High-throughput

0.618

High

1314030

HDAC2
Histone deacetylase 2

2

2

High-throughput

0.611

High

965561

NTF2
Nuclear transport factor 2

2

2

High-throughput

0.606

High

1314029

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

2

3

High-throughput

0.606

High

1314038

EAF1
ELL-associated factor 1

2

1

High-throughput

0.606

High

1314045

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

2

2

High-throughput

0.606

High

1314070

MARE3
Microtubule-associated protein RP/EB family member 3

2

1

High-throughput

0.606

High

1046386

UBXN1
UBX domain-containing protein 1

2

0

High-throughput

0.602

High

1162681

UBE2S
Ubiquitin-conjugating enzyme E2 S

2

0

High-throughput

0.602

High

1314035

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

2

0

High-throughput

0.602

High

485258

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.586

High

985758

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.586

High

372528

MYC
Myc proto-oncogene protein

2

7

Small-scale

0.585

High

261919

PP1RB
E3 ubiquitin-protein ligase PPP1R11

2

0

High-throughput

0.580

High

868731

LEG7
Galectin-7

2

0

High-throughput

0.580

High

1239869

CAVN1
Caveolae-associated protein 1

2

0

High-throughput

0.580

High

1314051

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1314061

IFT57
Intraflagellar transport protein 57 homolog

2

0

High-throughput

0.580

High

1314066

TLK1
Serine/threonine-protein kinase tousled-like 1

2

0

High-throughput

0.580

High

1314058

XAGE1
X antigen family member 1

2

1

High-throughput

0.571

High

443083

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

2

0

High-throughput

0.559

High

984463

RL30
Large ribosomal subunit protein eL30

2

0

High-throughput

0.559

High

167753

PCD17
Protocadherin-17

2

1

High-throughput

0.553

High

1208258

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

2

1

High-throughput

0.553

High

1208304

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

2

1

High-throughput

0.553

High

1314064

MARK1
Serine/threonine-protein kinase MARK1

2

2

High-throughput

0.553

High

675578

TYY1
Transcriptional repressor protein YY1

1

4

Small-scale

0.552

High

1314079

SETBP
SET-binding protein

1

0

High-throughput

0.549

High

951746

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.541

High

975115

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.536

High

1014155

CBX1
Chromobox protein homolog 1

1

12

High-throughput

0.536

High

1109876

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.536

High

1146732

PCBP1
Poly(rC)-binding protein 1

1

3

High-throughput

0.536

High

1243823

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

High-throughput

0.536

High

1291054

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

4

High-throughput

0.536

High

1279621

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

155681

FCHO1
F-BAR domain only protein 1

1

0

High-throughput

0.513

High

659138

LORI
Loricrin

1

0

High-throughput

0.513

High

1256957

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

1314036

ZN689
Zinc finger protein 689

1

0

High-throughput

0.513

High

1314043

DHB14
L-fucose dehydrogenase

1

0

High-throughput

0.513

High

465971

CO1A2
Collagen alpha-2(I) chain

1

1

High-throughput

0.489

High

1278533

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

1

High-throughput

0.489

High

1055662

GABP1
GA-binding protein subunit beta-1

1

5

Small-scale

0.481

High

1314039

ZFP42
Zinc finger protein 42 homolog

1

4

Small-scale

0.481

High

129765

CBX4
E3 SUMO-protein ligase CBX4

1

12

High-throughput

0.479

High

143109

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

181535

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

338896

CBX6
Chromobox protein homolog 6

1

12

High-throughput

0.479

High

461687

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468578

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

474117

NFIC
Nuclear factor 1 C-type

1

8

High-throughput

0.479

High

476748

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.479

High

481331

HMGB1
High mobility group protein B1

1

2

High-throughput

0.479

High

532754

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

535280

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

558261

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

559414

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.479

High

636112

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

662247

PAX7
Paired box protein Pax-7

1

3

High-throughput

0.479

High

662459

GATA2
Endothelial transcription factor GATA-2

1

3

High-throughput

0.479

High

662607

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

3

High-throughput

0.479

High

684303

DDX6
Probable ATP-dependent RNA helicase DDX6

1

5

High-throughput

0.479

High

685260

PAX6
Paired box protein Pax-6

1

3

High-throughput

0.479

High

691228

1433T
14-3-3 protein theta

1

6

High-throughput

0.479

High

724777

METK2
S-adenosylmethionine synthase isoform type-2

1

1

High-throughput

0.479

High

730040

1433B
14-3-3 protein beta/alpha

1

6

High-throughput

0.479

High

732354

PRDX2
Peroxiredoxin-2

1

2

High-throughput

0.479

High

778730

PRS7
26S proteasome regulatory subunit 7

1

4

High-throughput

0.479

High

908421

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.479

High

916684

PPP5
Serine/threonine-protein phosphatase 5

1

1

High-throughput

0.479

High

944701

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.479

High

954190

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

965772

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

3

High-throughput

0.479

High

971760

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

979958

H4
Histone H4

1

1

High-throughput

0.479

High

990475

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

1006858

PHC1
Polyhomeotic-like protein 1

1

9

High-throughput

0.479

High

1049537

1433F
14-3-3 protein eta

1

6

High-throughput

0.479

High

1050742

MAD1
Max dimerization protein 1

1

4

Small-scale

0.479

High

1052890

HME1
Homeobox protein engrailed-1

1

1

High-throughput

0.479

High

1066386

RBBP4
Histone-binding protein RBBP4

1

5

High-throughput

0.479

High

1087859

NFIA
Nuclear factor 1 A-type

1

7

High-throughput

0.479

High

1091315

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.479

High

1114931

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1132213

CBX2
Chromobox protein homolog 2

1

12

High-throughput

0.479

High

1133523

NFIX
Nuclear factor 1 X-type

1

7

High-throughput

0.479

High

1312456

PHC2
Polyhomeotic-like protein 2

1

7

High-throughput

0.479

High

1314020

PHC3
Polyhomeotic-like protein 3

1

8

High-throughput

0.479

High

1314021

CSK23
Casein kinase II subunit alpha 3

1

4

High-throughput

0.479

High

1314024

SP7
Transcription factor Sp7

1

3

High-throughput

0.479

High

1314028

DDX1
ATP-dependent RNA helicase DDX1

1

6

High-throughput

0.479

High

1314032

TNPO1
Transportin-1

1

2

High-throughput

0.479

High

1314037

SCMH1
Polycomb protein SCMH1

1

11

High-throughput

0.479

High

1314040

SRPK1
SRSF protein kinase 1

1

5

High-throughput

0.479

High

1314050

FOXQ1
Forkhead box protein Q1

1

2

High-throughput

0.479

High

1314055

CBX8
Chromobox protein homolog 8

1

12

High-throughput

0.479

High

1314065

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1314068

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1314071

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.479

High

109455

G5E9A7
DM1 locus, WD repeat containing

1

4

High-throughput

0.470

High

705455

GRN
Progranulin

1

1

High-throughput

0.470

High

131183

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.458

High

162362

PDCD5
Programmed cell death protein 5

1

0

Small-scale

0.458

High

211498

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

1

0

High-throughput

0.458

High

224018

GET3
ATPase GET3

1

0

High-throughput

0.458

High

228314

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

230055

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.458

High

365421

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

408978

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

428853

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

475398

RS17
Small ribosomal subunit protein eS17

1

0

High-throughput

0.458

High

537483

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

565968

EF2
Elongation factor 2

1

0

High-throughput

0.458

High

581690

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.458

High

596218

H12
Histone H1.2

1

0

High-throughput

0.458

High

720778

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

760963

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

809718

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

838134

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

High-throughput

0.458

High

859351

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

899756

PAPOA
Poly(A) polymerase alpha

1

0

High-throughput

0.458

High

959857

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.458

High

967491

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

968373

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.458

High

994649

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

996237

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

1153830

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

1274028

PHF5A
PHD finger-like domain-containing protein 5A

1

0

High-throughput

0.458

High

1314023

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1314042

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.458

High

1314049

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

1314054

CLK4
Dual specificity protein kinase CLK4

1

0

High-throughput

0.458

High

1314063

CDK12
Cyclin-dependent kinase 12

1

0

High-throughput

0.458

High

1314072

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.458

High

1314073

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

1314078

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.458

High

324011

CSTN1
Calsyntenin-1

1

3

High-throughput

0.445

High

414176

P53
Cellular tumor antigen p53

1

1

High-throughput

0.445

High

1150662

TRBP2
RISC-loading complex subunit TARBP2

1

2

High-throughput

0.445

High

1314052

TSYL2
Testis-specific Y-encoded-like protein 2

1

1

High-throughput

0.445

High

1314060

RNF12
E3 ubiquitin-protein ligase RLIM

1

1

High-throughput

0.445

High

1314069

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

Small-scale

0.445

High

1314077

DCAF1
DDB1- and CUL4-associated factor 1

1

4

High-throughput

0.445

High

75690

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

5

High-throughput

0.437

High

251933

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

1

High-throughput

0.437

High

920101

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.426

High

1004364

NOP14
Nucleolar protein 14

1

0

High-throughput

0.426

High

1149927

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.426

High

1208779

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.426

High

1258772

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.426

High

1314046

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.426

High

1314047

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.426

High

1314062

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.426

High

1314075

FCF1
rRNA-processing protein FCF1 homolog

1

0

High-throughput

0.426

High

69515

A2ML1
Alpha-2-macroglobulin-like protein 1

1

5

High-throughput

0.407

High

216322

MGA
Maltase-glucoamylase

1

1

High-throughput

0.407

High

1214698

Q5T8Z1
COMMD3-BMI1 readthrough

1

1

High-throughput

0.407

High

1314074

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

1

High-throughput

0.407

High

1314017

AGGF1
Angiogenic factor with G patch and FHA domains 1

2

0

High-throughput

0.328

High

1314025

CLM1
CMRF35-like molecule 1

2

0

High-throughput

0.316

High

1314059

DAAF6
Dynein axonemal assembly factor 6

2

0

High-throughput

0.316

High

1154322

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

1159397

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.279

Low

1244077

CXB7
Gap junction beta-7 protein

1

0

High-throughput

0.279

Low

1248702

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

1314067

MYH13
Myosin-13

1

0

High-throughput

0.279

Low

261836

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.249

Low

353436

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

903729

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025