HitPredict

Interactor 1: RFC4 (P35249)
Replication factor C subunit 4 (Activator 1 37 kDa subunit) (A1 37 kDa subunit) (Activator 1 subunit 4) (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37)
Gene: RFC4

Interactor 2: ATAD5 (Q96QE3)
ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)
Gene: ATAD5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	28514442, 33961781, 31160570, 24981860, 20147293
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~AAA, AAA~Rep_fac_C
Common GO terms	GO:0003677 - DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016887 - ATP hydrolysis activity GO:0031391 - Elg1 RFC-like complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 363 Hs			1 1844
+	Hs
		777906 RFC5_HUMAN (28-356): 5.29e-81: 252: 36.67		ATAD5_HUMAN (1-1844): 0: 1306: 100.00
+	Hs
		721934 RFC4_HUMAN (1-363): 7.79e-107: 319: 100.00		RFC1_HUMAN (433-1276): 4.59e-53: 207: 14.77
+	Hs
		722068 RFC2_HUMAN (1-358): 8.75e-87: 267: 33.80		RFC1_HUMAN (433-1276): 4.59e-53: 207: 14.77
+	Hs
		722015 RFC4_HUMAN (1-363): 7.79e-107: 319: 100.00		CTF18_HUMAN (998-1222): 2.17e-34: 146: 17.57
+	Hs
		722179 RFC5_HUMAN (28-356): 5.29e-81: 252: 36.67		RFC1_HUMAN (433-1276): 4.59e-53: 207: 14.77
+	Dm
		725339 Q9VX15_DROME (1-360): 2.34e-82: 256: 52.21		RFC1_DROME (609-1293): 8.06e-48: 189: 14.67
+	Dm
		725318 RFC2_DROME (24-356): 5.16e-79: 246: 35.74		RFC1_DROME (609-1293): 8.06e-48: 189: 14.67
+	Sp
		195246 RFC2_SCHPO (24-355): 6.02e-80: 249: 52.85		ELG1_SCHPO (730-1251): 1.44e-43: 175: 13.41
+	Sp
		144039 RFC3_SCHPO (31-356): 4.83e-79: 247: 34.56		ELG1_SCHPO (730-1251): 1.44e-43: 175: 13.41
+	Hs
		721989 RFC4_HUMAN (1-363): 7.79e-107: 319: 100.00		MDC1_HUMAN (10-849): 1.46e-20: 101: 8.33
+	Hs
		722134 RFC2_HUMAN (1-358): 8.75e-87: 267: 33.80		CTF18_HUMAN (998-1222): 2.17e-34: 146: 17.57
+	Sc
		772422 RFC2_YEAST (16-357): 4.46e-80: 250: 49.14		CTF18_YEAST (1020-1501): 1.12e-36: 152: 16.03
+	At
		1275801 RFC5_ARATH (5-360): 1.62e-76: 241: 36.36		RFC4_ARATH (1085-1330): 7e-42: 159: 14.79
+	Hs
		777901 RFC5_HUMAN (28-356): 5.29e-81: 252: 36.67		CTF18_HUMAN (998-1222): 2.17e-34: 146: 17.57
+	Sc
		751312 RFC2_YEAST (16-357): 4.46e-80: 250: 49.14		RFC1_YEAST (711-1292): 1.4e-34: 146: 14.55
+	Sc
		751278 RFC3_YEAST (29-360): 2.33e-76: 240: 34.42		CTF18_YEAST (1020-1501): 1.12e-36: 152: 16.03
+	Sc
		751260 RFC3_YEAST (29-360): 2.33e-76: 240: 34.42		RFC1_YEAST (711-1292): 1.4e-34: 146: 14.55
+	Zm
		75542 B4FJC2_MAIZE (36-360): 5.36e-80: 250: 37.12		B4FQT5_MAIZE (1085-1380): 3.28e-31: 128: 14.52
+	Hs
		722109 RFC2_HUMAN (1-358): 8.75e-87: 267: 33.80		MDC1_HUMAN (10-849): 1.46e-20: 101: 8.33
+	Hs
		777860 RFC5_HUMAN (28-356): 5.29e-81: 252: 36.67		MDC1_HUMAN (10-849): 1.46e-20: 101: 8.33