Protein: DIAP1
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)

Gene: DIAP1, DIAPH1
Organism: Homo sapiens
Interactions: 118
UniProt ID: O60610

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003779 - actin binding
GO:0005102 - signaling receptor binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

126390

RHOD
Rho-related GTP-binding protein RhoD

5

20

Small-scale

0.924

High

252406

RHOC
Rho-related GTP-binding protein RhoC

4

20

Small-scale

0.899

High

252434

RHOA
Transforming protein RhoA

3

20

Small-scale

0.863

High

252439

RHOB
Rho-related GTP-binding protein RhoB

3

20

Small-scale

0.834

High

252486

RHOF
Rho-related GTP-binding protein RhoF

2

20

Small-scale

0.768

High

252435

DCAF7
DDB1- and CUL4-associated factor 7

6

2

Small-scale

0.735

High

252483

RAB34
Ras-related protein Rab-34

1

12

High-throughput

0.691

High

252391

DIAP1
Protein diaphanous homolog 1

1

11

Small-scale

0.647

High

252432

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.647

High

252405

HS90A
Heat shock protein HSP 90-alpha

3

4

High-throughput

0.640

High

252419

PROF2
Profilin-2

2

10

High-throughput

0.628

High

252401

RASK
GTPase KRas

1

15

High-throughput

0.618

High

252430

ACTB
Actin, cytoplasmic 1

1

13

High-throughput

0.618

High

252431

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

252441

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

252442

ACTC
Actin, alpha cardiac muscle 1

1

11

High-throughput

0.618

High

252443

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

252446

RB40B
Ras-related protein Rab-40B

1

6

Small-scale

0.618

High

252454

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.618

High

252482

CDC5L
Cell division cycle 5-like protein

2

1

High-throughput

0.606

High

252395

PR40A
Pre-mRNA-processing factor 40 homolog A

2

12

High-throughput

0.605

High

252424

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

4

Small-scale

0.584

High

252456

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

2

6

High-throughput

0.574

High

252415

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

163669

TCRG1
Transcription elongation regulator 1

1

9

High-throughput

0.561

High

252457

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.552

High

252399

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.541

High

252427

PPM1F
Protein phosphatase 1F

1

0

Small-scale

0.537

High

190180

MOT4
Monocarboxylate transporter 4

1

2

High-throughput

0.536

High

208110

PLXB1
Plexin-B1

1

2

High-throughput

0.536

High

252402

FINC
Fibronectin

1

1

High-throughput

0.536

High

252412

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

252440

GRB2
Growth factor receptor-bound protein 2

1

10

High-throughput

0.536

High

252444

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

High-throughput

0.536

High

252445

FOXO1
Forkhead box protein O1

1

2

High-throughput

0.536

High

252450

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

252459

TUT7
Terminal uridylyltransferase 7

1

2

High-throughput

0.536

High

252495

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

252453

RAGE
Advanced glycosylation end product-specific receptor

1

5

Small-scale

0.529

High

252408

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

Small-scale

0.529

High

252392

GAS7
Growth arrest-specific protein 7

1

7

High-throughput

0.527

High

252396

WBP4
WW domain-binding protein 4

1

6

High-throughput

0.527

High

252474

H2B1H
Histone H2B type 1-H

1

3

High-throughput

0.515

High

252397

CSPG5
Chondroitin sulfate proteoglycan 5

1

0

High-throughput

0.513

High

252455

ZN284
Zinc finger protein 284

1

0

High-throughput

0.513

High

252494

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

126929

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.501

High

252423

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

High-throughput

0.501

High

64967

SWAHB
Ankyrin repeat domain-containing protein SOWAHB

1

4

High-throughput

0.489

High

252481

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

252488

DJB12
DnaJ homolog subfamily B member 12

1

2

High-throughput

0.489

High

252426

CENPA
Histone H3-like centromeric protein A

1

5

Small-scale

0.481

High

240232

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

252393

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

252394

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

5

Small-scale

0.479

High

252400

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

252403

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

252404

PROF1
Profilin-1

1

10

High-throughput

0.479

High

252409

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

252413

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

252414

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.479

High

252416

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

252417

CLIP1
CAP-Gly domain-containing linker protein 1

1

5

Small-scale

0.479

High

252421

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

252422

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

252429

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

252436

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

252437

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.479

High

252438

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

252447

CDC16
Cell division cycle protein 16 homolog

1

6

High-throughput

0.479

High

252448

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

252449

PKD2
Polycystin-2

1

1

Small-scale

0.479

High

252451

ARHG7
Rho guanine nucleotide exchange factor 7

1

1

High-throughput

0.479

High

252452

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

252464

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

252465

H32
Histone H3.2

1

5

High-throughput

0.479

High

252466

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

252467

PABP2
Polyadenylate-binding protein 2

1

3

High-throughput

0.479

High

252468

FBXW8
F-box/WD repeat-containing protein 8

1

4

High-throughput

0.479

High

252470

PHIP
PH-interacting protein

1

2

High-throughput

0.479

High

252471

ASB11
Ankyrin repeat and SOCS box protein 11

1

3

High-throughput

0.479

High

252472

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

252473

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

252477

DOCK7
Dedicator of cytokinesis protein 7

1

1

High-throughput

0.479

High

252480

RUFY1
RUN and FYVE domain-containing protein 1

1

6

High-throughput

0.479

High

252485

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

252490

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

252491

ANFY1
Rabankyrin-5

1

2

High-throughput

0.479

High

252492

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

252493

TES
Testin

1

1

High-throughput

0.479

High

229598

CALU
Calumenin

1

1

High-throughput

0.470

High

186280

PMM2
Phosphomannomutase 2

1

0

High-throughput

0.458

High

193916

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

252410

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.458

High

252411

SKI
Ski oncogene

1

0

Small-scale

0.458

High

252418

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

252428

ATX1
Ataxin-1

1

0

High-throughput

0.458

High

252433

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

252460

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

252461

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.458

High

252463

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

252478

XPO6
Exportin-6

1

0

Small-scale

0.458

High

252479

CCNL2
Cyclin-L2

1

0

High-throughput

0.458

High

252489

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

108076

G3V4T2
Polyadenylate-binding protein 2

1

3

High-throughput

0.445

High

252407

HCK
Tyrosine-protein kinase HCK

1

11

Small-scale

0.445

High

252469

CE192
Centrosomal protein of 192 kDa

1

1

High-throughput

0.445

High

252484

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

252398

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

252420

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

252462

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

252487

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

252476

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

252458

Q5T8C6
Cell division cycle 16

1

5

High-throughput

0.407

High

252475

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

252425

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

62426

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025