HitPredict

Interactor 1: ADA1A (P35348)
Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c)
Gene: ADRA1A

Interactor 2: ADA1A (P35348)
Alpha-1A adrenergic receptor (Alpha-1A adrenoreceptor) (Alpha-1A adrenoceptor) (Alpha-1C adrenergic receptor) (Alpha-adrenergic receptor 1c)
Gene: ADRA1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 12888550, 14645668
Identification Methods fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~7tm_1
Common GO terms GO:0000165 - MAPK cascade
GO:0001985 - negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 - norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 - positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 - positive regulation of the force of heart contraction by epinephrine-norepinephrine
and 37 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 466
Hs

1 466
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024