Protein: RPC2
DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B)

Gene: RPC2, POLR3B
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q9NW08

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005654 - nucleoplasm
GO:0005666 - RNA polymerase III complex
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1450818

RPC5
DNA-directed RNA polymerase III subunit RPC5

7

3

Small-scale

0.963

High

430653

RPC4
DNA-directed RNA polymerase III subunit RPC4

7

3

Small-scale

0.962

High

165100

RPC1
DNA-directed RNA polymerase III subunit RPC1

7

20

Small-scale

0.954

High

180415

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

5

17

Small-scale

0.925

High

959073

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

5

8

Small-scale

0.925

High

1451015

RPC8
DNA-directed RNA polymerase III subunit RPC8

5

11

Small-scale

0.919

High

983719

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

5

9

Small-scale

0.916

High

1451014

RPC10
DNA-directed RNA polymerase III subunit RPC10

5

12

Small-scale

0.916

High

923554

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

4

6

Small-scale

0.881

High

287489

RPC9
DNA-directed RNA polymerase III subunit RPC9

3

3

Small-scale

0.839

High

1431037

RPC6
DNA-directed RNA polymerase III subunit RPC6

2

2

Small-scale

0.776

High

621769

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

17

High-throughput

0.754

High

621989

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

6

10

Small-scale

0.734

High

516879

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

2

9

High-throughput

0.712

High

1451007

UXT
Protein UXT

4

2

High-throughput

0.699

High

1413121

RPC7L
DNA-directed RNA polymerase III subunit RPC7-like

4

1

High-throughput

0.697

High

1451003

PIHD1
PIH1 domain-containing protein 1

4

2

High-throughput

0.694

High

1371360

TF3B
Transcription factor IIIB 90 kDa subunit

1

5

High-throughput

0.691

High

1439335

GPN1
GPN-loop GTPase 1

4

13

High-throughput

0.691

High

316451

RMP
Unconventional prefoldin RPB5 interactor 1

4

3

Small-scale

0.686

High

786883

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

3

4

High-throughput

0.667

High

1435182

RPAP3
RNA polymerase II-associated protein 3

3

7

High-throughput

0.667

High

1451009

PFD2
Prefoldin subunit 2

3

2

High-throughput

0.667

High

414718

P53
Cellular tumor antigen p53

1

1

High-throughput

0.665

High

1451010

GPN3
GPN-loop GTPase 3

5

13

High-throughput

0.654

High

186385

RPC7
DNA-directed RNA polymerase III subunit RPC7

3

1

Small-scale

0.650

High

912139

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

6

Small-scale

0.650

High

191126

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.618

High

192869

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

3

High-throughput

0.618

High

340044

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

20

High-throughput

0.618

High

667480

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

20

High-throughput

0.618

High

723116

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

10

High-throughput

0.618

High

787799

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

12

High-throughput

0.618

High

912247

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

9

High-throughput

0.618

High

976162

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

11

High-throughput

0.618

High

1428648

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

5

High-throughput

0.618

High

1437315

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

10

High-throughput

0.618

High

1451005

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

13

High-throughput

0.618

High

182195

PFD6
Prefoldin subunit 6

2

4

High-throughput

0.611

High

1429446

MAF1
Repressor of RNA polymerase III transcription MAF1 homolog

2

1

High-throughput

0.611

High

1414280

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

3

Small-scale

0.601

High

243100

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

1313062

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

3

High-throughput

0.584

High

1451001

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

10

Small-scale

0.575

High

64441

BDP1
Transcription factor TFIIIB component B'' homolog

1

2

High-throughput

0.536

High

625661

CSK22
Casein kinase II subunit alpha'

1

6

High-throughput

0.536

High

628848

TBP
TATA-box-binding protein

1

4

High-throughput

0.536

High

854344

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

891330

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.536

High

998062

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.536

High

1144186

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1326115

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.536

High

724204

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.515

High

136005

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.513

High

191406

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

846499

MATR3
Matrin-3

1

0

High-throughput

0.513

High

1054657

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.513

High

1275507

TRM1L
tRNA

1

0

High-throughput

0.513

High

1433047

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.513

High

1451006

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.513

High

249206

DSCAM
Cell adhesion molecule DSCAM

1

2

High-throughput

0.494

High

1016382

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.493

High

848732

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

1337804

DP13B
DCC-interacting protein 13-beta

1

2

High-throughput

0.489

High

260526

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

373291

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

407134

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.479

High

412695

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

589845

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

696665

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

769331

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

911406

IMA5
Importin subunit alpha-5

1

5

High-throughput

0.479

High

968000

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

High-throughput

0.479

High

971170

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

1008381

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

High-throughput

0.479

High

1054797

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.479

High

1100451

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1106094

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

1217624

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

11

High-throughput

0.479

High

1233957

Q6ICH2
single-stranded DNA cytosine deaminase

1

2

High-throughput

0.479

High

1255787

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1276334

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1292814

SKAP1
Src kinase-associated phosphoprotein 1

1

3

High-throughput

0.479

High

1360830

ASB11
Ankyrin repeat and SOCS box protein 11

1

4

High-throughput

0.479

High

1399366

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

13

High-throughput

0.479

High

1411732

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1416239

RPAP1
RNA polymerase II-associated protein 1

1

3

High-throughput

0.479

High

1434041

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1446523

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.479

High

1447087

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

14

High-throughput

0.479

High

1449779

PDRG1
p53 and DNA damage-regulated protein 1

1

2

High-throughput

0.479

High

1451004

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1451008

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1451011

XPO7
Exportin-7

1

3

High-throughput

0.479

High

567499

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

1007795

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.458

High

117732

ASURF
ASNSD1 upstream open reading frame protein

1

1

High-throughput

0.445

High

516808

RPC22
Protein POLR1D, isoform 2

1

1

High-throughput

0.445

High

911131

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.445

High

944081

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

1295473

S13A5
Na(+)/citrate cotransporter

1

1

High-throughput

0.445

High

1383334

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

2

High-throughput

0.445

High

1449950

S39A9
Zinc transporter ZIP9

1

2

High-throughput

0.445

High

1141333

BRD3
Bromodomain-containing protein 3

1

8

High-throughput

0.437

High

1232030

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

2

High-throughput

0.437

High

1332239

KRI1
Protein KRI1 homolog

1

1

High-throughput

0.437

High

1398618

DAA10
Dynein axonemal assembly factor 10

1

3

High-throughput

0.437

High

1433450

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

1451002

ASND1
Asparagine synthetase domain-containing protein 1

1

3

High-throughput

0.437

High

1451013

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

132927

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.426

High

239226

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.426

High

664908

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

51505

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

3

High-throughput

0.407

High

1251812

S39A5
Zinc transporter ZIP5

1

2

High-throughput

0.407

High

1421365

S39A8
Metal cation symporter ZIP8

1

2

High-throughput

0.407

High

1451012

S13A4
Solute carrier family 13 member 4

1

1

High-throughput

0.407

High

389611

RET4
Retinol-binding protein 4

1

0

High-throughput

0.279

Low

1357251

S38A5
Sodium-coupled neutral amino acid transporter 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025