HitPredict

Interactor 1: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	15522123
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1242 Hs			1 488
+	Mm
		724589 IRS1_MOUSE (1-1242): 8.26e-132: 436: 86.59		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		151790 IRS4_HUMAN (11-1066): 3.82e-80: 290: 22.24		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038846 IRS2_HUMAN (13-1215): 1.58e-76: 279: 29.33		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1270347 CBP_HUMAN (280-1238): 5.8e-36: 151: 12.68		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038592 CBP_HUMAN (280-1238): 5.8e-36: 151: 12.68		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177346 CBP_HUMAN (280-1238): 5.8e-36: 151: 12.68		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Hs
		110768 H7BXF5_HUMAN (394-1222): 6.61e-14: 78.8: 8.38		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		101450 F8VPR5_MOUSE (280-1238): 2.76e-37: 155: 12.89		HDA10_MOUSE (12-394): 1.09e-139: 418: 23.06
+	Hs
		1056969 MDC1_HUMAN (356-1239): 1.69e-20: 100: 10.39		HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40
+	Mm
		88461 D3Z656_MOUSE (852-1242): 1.06e-11: 71.9: 12.04		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Mm
		1157748 SYNJ1_MOUSE (877-1242): 1.2e-10: 68.4: 13.16		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89