HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: SMD3 (P62318)
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)
Gene: SNRPD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29884807, 27460707
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008380 - RNA splicing
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 126
+	Hs
		912691 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SMD3_HUMAN (1-126): 1.77e-42: 137: 100.00
+	Hs
		912344 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		SMD1_HUMAN (7-94): 9.52e-33: 112: 27.27
+	Hs
		727115 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		LSM4_HUMAN (5-84): 8.75e-35: 118: 30.86
+	Hs
		912618 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SMD3_HUMAN (1-126): 1.77e-42: 137: 100.00
+	Hs
		726708 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		SMD1_HUMAN (7-94): 9.52e-33: 112: 27.27
+	Hs
		912755 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		SMD3_HUMAN (1-126): 1.77e-42: 137: 100.00
+	Hs
		911919 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66
+	Hs
		726707 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66
+	Hs
		912271 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SMD1_HUMAN (7-94): 9.52e-33: 112: 27.27
+	Hs
		911809 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66
+	Hs
		911997 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66
+	Dm
		218382 Q9W424_DROME (265-407): 1.99e-18: 88.8: 19.61		SMD3_DROME (1-107): 1.78e-37: 125: 83.18
+	Hs
		912012 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66
+	Hs
		212121 HTSF1_HUMAN (267-372): 6.19e-23: 104: 21.30		RUXF_HUMAN (1-72): 4.64e-28: 100: 24.66
+	Sc
		376759 PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49		LSM2_YEAST (8-90): 6.74e-27: 97.3: 17.65
+	Sc
		376804 PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49		LSM4_YEAST (5-81): 4.74e-22: 87.8: 26.14