HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 768
+	Hs
		1042197 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Mm
		882704 FUS_MOUSE (1-526): 6.91e-34: 136: 86.72		CUL3_MOUSE (1-768): 0: 949: 99.48
+	Hs
		967158 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		212139 HTSF1_HUMAN (267-372): 6.19e-23: 104: 21.30		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1043138 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		726804 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043490 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		726805 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		967159 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		967160 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1041126 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		726801 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		967156 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1041420 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		726802 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		967157 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1031315 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1271154 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		726974 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		967326 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		CUL5_HUMAN (25-768): 0: 597: 23.77