HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: ATX2L (Q8WWM7)
Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein)
Gene: ATXN2L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	25192599, 27460707
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 1075
+	Hs
		1031402 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		ATX2L_HUMAN (1-1075): 6.36e-139: 447: 100.00
+	Hs
		516606 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		ATX2L_HUMAN (1-1075): 6.36e-139: 447: 100.00
+	Hs
		726817 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		MDC1_HUMAN (4-779): 4.69e-18: 92.3: 9.29
+	At
		248502 PABP3_ARATH (228-385): 4.44e-14: 77: 17.09		CID4_ARATH (76-635): 3.2e-41: 163: 16.28
+	At
		790113 PABP2_ARATH (284-379): 1.74e-12: 72: 28.13		CID4_ARATH (76-635): 3.2e-41: 163: 16.28
+	At
		983453 PABP5_ARATH (228-381): 4.79e-12: 70.5: 16.23		CID4_ARATH (76-635): 3.2e-41: 163: 16.28
+	At
		1277466 PABP8_ARATH (287-379): 7.68e-10: 63.5: 20.43		CID4_ARATH (76-635): 3.2e-41: 163: 16.28
+	Hs
		967173 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		MDC1_HUMAN (4-779): 4.69e-18: 92.3: 9.29
+	Hs
		131713 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		BCL9_HUMAN (390-1060): 6.31e-16: 85.4: 11.00
+	Mm
		250686 FUS_MOUSE (1-526): 6.91e-34: 136: 86.72		ATX2_MOUSE (28-840): 1.25e-13: 77.7: 9.44
+	Hs
		967541 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		PCLO_HUMAN (9-1035): 8.82e-15: 81.9: 9.88
+	Hs
		867093 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		SC24C_HUMAN (613-1018): 1.53e-10: 67.5: 11.79
+	Sc
		376873 PABP_YEAST (263-381): 1.57e-10: 65.5: 18.49		PBP1_YEAST (86-726): 2.04e-27: 121: 16.04
+	Hs
		1305733 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		ATX2_HUMAN (176-847): 3.45e-11: 70: 10.82
+	Hs
		1031438 PABP4_HUMAN (280-379): 4.96e-13: 73.5: 22.00		ATX2_HUMAN (176-847): 3.45e-11: 70: 10.82
+	Hs
		516661 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		ATX2_HUMAN (176-847): 3.45e-11: 70: 10.82
+	Hs
		516595 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		KMT2C_HUMAN (325-862): 6.44e-10: 66.1: 10.78