Protein: ERC6L
DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)

Gene: ERC6L, ERCC6L
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q2NKX8

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0003677 - DNA binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1179239

WDFY2
WD repeat and FYVE domain-containing protein 2

3

14

High-throughput

0.770

High

920000

PLK1
Serine/threonine-protein kinase PLK1

10

12

Small-scale

0.756

High

1179235

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

946120

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.638

High

1179218

TFDP3
Transcription factor Dp family member 3

3

0

High-throughput

0.638

High

843608

HD
Huntingtin

2

1

High-throughput

0.637

High

1149411

SIX1
Homeobox protein SIX1

2

6

High-throughput

0.628

High

1179217

MIDN
Midnolin

2

1

High-throughput

0.628

High

1179219

A16L1
Autophagy-related protein 16-1

1

14

High-throughput

0.618

High

1179258

FBW1B
F-box/WD repeat-containing protein 11

1

20

High-throughput

0.618

High

163114

CHK1
Serine/threonine-protein kinase Chk1

2

0

High-throughput

0.602

High

488227

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.602

High

1179245

AASD1
Alanyl-tRNA editing protein Aarsd1

2

0

High-throughput

0.602

High

768326

RFA3
Replication protein A 14 kDa subunit

2

8

High-throughput

0.601

High

926363

BLM
RecQ-like DNA helicase BLM

1

18

High-throughput

0.575

High

1106422

TOP3A
DNA topoisomerase 3-alpha

1

2

High-throughput

0.575

High

1179254

SIX2
Homeobox protein SIX2

2

12

High-throughput

0.574

High

730624

1433S
14-3-3 protein sigma

2

10

High-throughput

0.571

High

1049344

1433F
14-3-3 protein eta

1

10

High-throughput

0.554

High

1179223

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

155669

FCHO1
F-BAR domain only protein 1

1

1

High-throughput

0.536

High

358699

LDHA
L-lactate dehydrogenase A chain

1

1

High-throughput

0.536

High

660638

IF4B
Eukaryotic translation initiation factor 4B

1

8

High-throughput

0.536

High

930907

HSP72
Heat shock-related 70 kDa protein 2

1

12

High-throughput

0.536

High

966382

1433G
14-3-3 protein gamma

1

10

High-throughput

0.536

High

1179230

MINK1
Misshapen-like kinase 1

1

5

High-throughput

0.536

High

1179236

EFMT3
EEF1A lysine methyltransferase 3

1

5

High-throughput

0.536

High

1179240

PASK
PAS domain-containing serine/threonine-protein kinase

1

2

High-throughput

0.536

High

1179241

TCPQM
T-complex protein 1 subunit theta-like 2

1

4

High-throughput

0.536

High

1179242

CDC5L
Cell division cycle 5-like protein

1

18

High-throughput

0.536

High

1179244

FEM1A
Protein fem-1 homolog A

1

6

High-throughput

0.536

High

1179246

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

1179247

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

965461

LMO4
LIM domain transcription factor LMO4

1

13

High-throughput

0.523

High

1179231

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.515

High

606003

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

1179228

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1179255

CN119
Uncharacterized protein C14orf119

1

0

High-throughput

0.513

High

1179257

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.513

High

443387

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.501

High

1179227

ZDH17
Palmitoyltransferase ZDHHC17

1

9

High-throughput

0.494

High

74505

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

15

High-throughput

0.489

High

238713

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

1

High-throughput

0.489

High

674186

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.489

High

767446

RADI
Radixin

1

5

High-throughput

0.489

High

563843

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.481

High

172874

XPO1
Exportin-1

1

8

High-throughput

0.479

High

241841

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

293768

CD123
Translation initiation factor eIF2 assembly protein

1

5

High-throughput

0.479

High

373960

RASN
GTPase NRas

1

3

High-throughput

0.479

High

404096

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

412023

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

635531

NEBU
Nebulin

1

7

High-throughput

0.479

High

642903

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

675042

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.479

High

695600

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

15

High-throughput

0.479

High

714165

PML
Protein PML

1

18

High-throughput

0.479

High

731347

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

830837

CCNF
Cyclin-F

1

8

High-throughput

0.479

High

1096709

RFA4
Replication protein A 30 kDa subunit

1

11

High-throughput

0.479

High

1106560

SMAD4
Mothers against decapentaplegic homolog 4

1

3

High-throughput

0.479

High

1107776

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1141634

EEA1
Early endosome antigen 1

1

19

High-throughput

0.479

High

1179216

AMOT
Angiomotin

1

18

High-throughput

0.479

High

1179225

NAA40
N-alpha-acetyltransferase 40

1

7

High-throughput

0.479

High

1179232

ASB11
Ankyrin repeat and SOCS box protein 11

1

9

High-throughput

0.479

High

1179234

GOGA1
Golgin subfamily A member 1

1

10

High-throughput

0.479

High

1179238

SNX27
Sorting nexin-27

1

2

High-throughput

0.479

High

1179243

BARD1
BRCA1-associated RING domain protein 1

1

10

High-throughput

0.479

High

1179248

WWTR1
WW domain-containing transcription regulator protein 1

1

15

High-throughput

0.479

High

1179249

CLPB
Mitochondrial disaggregase

1

9

High-throughput

0.479

High

1179252

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.479

High

1179256

BCLF1
Bcl-2-associated transcription factor 1

1

9

High-throughput

0.479

High

301448

WFS1
Wolframin

1

1

High-throughput

0.470

High

1179222

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

231583

PRKY
Putative serine/threonine-protein kinase PRKY

1

4

High-throughput

0.445

High

437690

HEPS
Serine protease hepsin

1

3

High-throughput

0.445

High

541026

PIM1
Serine/threonine-protein kinase pim-1

1

3

High-throughput

0.445

High

640180

EPHA1
Ephrin type-A receptor 1

1

5

High-throughput

0.445

High

896390

ERF
ETS domain-containing transcription factor ERF

1

20

High-throughput

0.445

High

1030169

IL5RA
Interleukin-5 receptor subunit alpha

1

4

High-throughput

0.445

High

1179220

ARMC6
Armadillo repeat-containing protein 6

1

2

High-throughput

0.445

High

1179226

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

8

High-throughput

0.445

High

1179229

FXL16
F-box/LRR-repeat protein 16

1

2

High-throughput

0.445

High

1179237

AURKB
Aurora kinase B

1

6

High-throughput

0.445

High

588828

RFA2
Replication protein A 32 kDa subunit

1

11

High-throughput

0.437

High

1179221

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1179224

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

17

High-throughput

0.437

High

1179251

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.437

High

248883

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

607930

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

0

High-throughput

0.426

High

889922

VEGFB
Vascular endothelial growth factor B

1

0

High-throughput

0.426

High

898476

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.426

High

466901

ACM4
Muscarinic acetylcholine receptor M4

1

2

High-throughput

0.407

High

628412

KLK2
Kallikrein-2

1

10

High-throughput

0.407

High

1179233

LPAR1
Lysophosphatidic acid receptor 1

1

7

High-throughput

0.407

High

1179250

DJC25
DnaJ homolog subfamily C member 25

1

6

High-throughput

0.407

High

66890

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

1178820

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

106034

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

342573

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.232

Low

1179253

RMI1
RecQ-mediated genome instability protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025