HitPredict

Interactor 1: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Interactor 2: RALY (Q9UKM9)
RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)
Gene: RALY

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	29884807, 35271311, 30354839
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003712 - transcription coregulator activity GO:0003723 - RNA binding GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 526 Hs			1 306
+	Mm
		1144850 Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34		RALY_MOUSE (1-306): 9.64e-160: 449: 85.58
+	Mm
		882689 FUS_MOUSE (1-526): 6.91e-34: 136: 86.72		RALY_MOUSE (1-306): 9.64e-160: 449: 85.58
+	Mm
		1142748 EWS_MOUSE (3-451): 2.8e-30: 127: 35.56		RALY_MOUSE (1-306): 9.64e-160: 449: 85.58
+	Hs
		1356521 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		RALY_HUMAN (1-306): 1.15e-143: 408: 100.00
+	Mm
		665756 PABP1_MOUSE (184-382): 3.6e-12: 70.8: 12.44		RALY_MOUSE (1-306): 9.64e-160: 449: 85.58
+	Hs
		516734 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		RALY_HUMAN (1-306): 1.15e-143: 408: 100.00
+	Hs
		432837 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		HNRPC_HUMAN (6-219): 3.17e-99: 295: 52.38
+	Hs
		241339 RBP56_HUMAN (42-460): 2.62e-42: 161: 48.10		HNRC1_HUMAN (6-297): 1.05e-98: 293: 43.43
+	Hs
		432577 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		HNRPC_HUMAN (6-219): 3.17e-99: 295: 52.38
+	Hs
		241277 FUS_HUMAN (1-526): 1.99e-39: 152: 100.00		HNRC1_HUMAN (6-297): 1.05e-98: 293: 43.43
+	Hs
		967252 EWS_HUMAN (3-451): 5.13e-31: 129: 31.05		RALYL_HUMAN (1-224): 3.08e-105: 310: 64.83
+	Hs
		1197556 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		RALYL_HUMAN (1-224): 3.08e-105: 310: 64.83
+	Hs
		432996 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		HNRPC_HUMAN (6-219): 3.17e-99: 295: 52.38
+	Hs
		241386 PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46		HNRC1_HUMAN (6-297): 1.05e-98: 293: 43.43
+	Hs
		433014 RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35		HNRPC_HUMAN (6-219): 3.17e-99: 295: 52.38
+	Hs
		432527 PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44		HNRPC_HUMAN (6-219): 3.17e-99: 295: 52.38