Protein: IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH)

Gene: IDH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 99
UniProt ID: P28834

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004449 - isocitrate dehydrogenase (NAD+) activity
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

701494

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

14

17

Small-scale

0.981

High

642125

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

5

High-throughput

0.618

High

510270

HSP77
Import motor subunit, mitochondrial

2

8

High-throughput

0.584

High

512306

RS6A
Small ribosomal subunit protein eS6A

2

2

High-throughput

0.584

High

578983

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.584

High

604918

MDHM
Malate dehydrogenase, mitochondrial

2

7

Small-scale

0.584

High

705758

MIC60
MICOS complex subunit MIC60

2

2

High-throughput

0.584

High

705748

MKK2
MAP kinase kinase MKK2/SSP33

1

5

High-throughput

0.536

High

705754

SPT7
SAGA complex subunit SPT7

1

1

High-throughput

0.536

High

705768

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.536

High

705786

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

4

High-throughput

0.536

High

533161

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

0

High-throughput

0.513

High

705744

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.513

High

705774

BNI1
Protein BNI1

1

2

High-throughput

0.501

High

705762

IMB2
Importin subunit beta-2

1

4

High-throughput

0.500

High

705779

RPN14
26S proteasome regulatory subunit RPN14

1

9

High-throughput

0.500

High

470111

SPS1
Sporulation-specific protein 1

1

1

High-throughput

0.489

High

705773

COPB2
Coatomer subunit beta'

1

7

High-throughput

0.489

High

705790

KU80
ATP-dependent DNA helicase II subunit 2

1

1

High-throughput

0.489

High

705787

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.479

High

149633

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

383567

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.479

High

392360

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

409980

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

434893

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

435825

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

441755

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

452639

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

1

High-throughput

0.479

High

454925

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

502897

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

504081

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.479

High

512869

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.479

High

518231

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.479

High

523270

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.479

High

646324

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.479

High

654587

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.479

High

670417

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

674465

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

679448

CDC48
Cell division control protein 48

1

6

High-throughput

0.479

High

682188

SPB4
ATP-dependent rRNA helicase SPB4

1

4

High-throughput

0.479

High

685098

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

1

High-throughput

0.479

High

689311

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

694462

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

705745

HS104
Heat shock protein 104

1

4

High-throughput

0.479

High

705749

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.479

High

705750

PREP
Presequence protease, mitochondrial

1

4

High-throughput

0.479

High

705751

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.479

High

705752

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.479

High

705753

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

705757

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

705759

LONM
Lon protease homolog, mitochondrial

1

10

High-throughput

0.479

High

705760

GBLP
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.479

High

705763

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

705767

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

705770

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

1

High-throughput

0.479

High

705777

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

705783

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

705785

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

705788

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

705789

ABF2
ARS-binding factor 2, mitochondrial

1

4

Small-scale

0.479

High

705791

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.479

High

705795

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

705799

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

705801

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.479

High

705802

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

382851

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

705780

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

517932

SSBP1
Single-stranded nucleic acid-binding protein

1

2

High-throughput

0.457

High

633443

PP11
Serine/threonine-protein phosphatase PP1-1

1

2

High-throughput

0.457

High

637180

PWP1
Periodic tryptophan protein 1

1

7

High-throughput

0.457

High

675277

DMC1
Meiotic recombination protein DMC1

1

1

High-throughput

0.457

High

705766

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.457

High

544067

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

705771

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

705772

ATAD2
ATPase histone chaperone YTA7

1

8

High-throughput

0.445

High

705743

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

705746

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.437

High

705747

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.437

High

705755

SPT10
Protein SPT10

1

1

High-throughput

0.437

High

705756

SPT21
Protein SPT21

1

1

High-throughput

0.437

High

705775

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.437

High

705778

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

705782

GIS2
Zinc finger protein GIS2

1

3

High-throughput

0.437

High

705784

H3
Histone H3

1

2

High-throughput

0.437

High

705792

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

705798

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

705761

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.417

High

705765

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.407

High

705769

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

2

High-throughput

0.407

High

575572

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

0

High-throughput

0.279

Low

705793

RBX1
RING-box protein HRT1

1

0

High-throughput

0.279

Low

705800

HRT3
F-box protein HRT3

1

0

High-throughput

0.279

Low

705764

RGD3
Rho-GTPase-activating protein RGD3

1

0

High-throughput

0.269

Low

705776

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

705781

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.249

Low

705794

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

705796

YP191
Ubiquitin carboxyl-terminal hydrolase MIY1

1

0

High-throughput

0.249

Low

705797

HFI1
SAGA complex subunit HFI1

1

0

Small-scale

0.249

Low

419634

H2A2
Histone H2A.2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025