HitPredict

Interactor 1: PRDX1 (P35700)
Peroxiredoxin-1 (EC 1.11.1.24) (Macrophage 23 kDa stress protein) (Osteoblast-specific factor 3) (OSF-3) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)
Gene: PRDX1

Interactor 2: THIOM (P97493)
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
Gene: Txn2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	31018154
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	GO:0005739 - mitochondrion GO:0006979 - response to oxidative stress GO:0045454 - cell redox homeostasis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 199 Mm			1 166
+	Mm
		956730 PRDX2_MOUSE (1-198): 1.15e-101: 293: 74.75		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		589514 PRDX3_MOUSE (2-197): 7e-95: 278: 61.74		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Mm
		139927 PRDX4_MOUSE (4-197): 3.44e-94: 277: 67.53		THIOM_MOUSE (1-166): 1.73e-53: 168: 100.00
+	Hs
		495510 PRDX1_HUMAN (1-199): 2.93e-103: 297: 95.48		THIO_HUMAN (61-165): 1.71e-36: 123: 34.91
+	Hs
		495475 PRDX2_HUMAN (1-198): 1.65e-101: 293: 76.26		THIO_HUMAN (61-165): 1.71e-36: 123: 34.91
+	Hs
		423216 PRDX4_HUMAN (4-197): 2.33e-93: 274: 68.04		PDIA1_HUMAN (52-166): 3.4e-34: 127: 27.50
+	Hs
		1026686 PRDX4_HUMAN (4-197): 2.33e-93: 274: 68.04		PDIA6_HUMAN (62-165): 2.6e-32: 121: 23.81
+	Hs
		531737 PRDX3_HUMAN (2-197): 1e-96: 283: 61.22		PDIA4_HUMAN (60-165): 1.07e-28: 112: 27.52
+	So
		188731 BAS1_SPIOL (8-196): 4.99e-86: 256: 59.47		TRXM_SPIOL (14-165): 2.43e-39: 133: 23.03
+	Hs
		671804 PRDX4_HUMAN (4-197): 2.33e-93: 274: 68.04		PDIA3_HUMAN (49-163): 5.5e-30: 115: 23.53
+	Hs
		531815 PRDX4_HUMAN (4-197): 2.33e-93: 274: 68.04		PDIA4_HUMAN (60-165): 1.07e-28: 112: 27.52
+	Rn
		751965 PRDX4_RAT (4-197): 1.05e-93: 276: 67.53		PDIA4_RAT (16-165): 5.3e-28: 110: 23.23
+	Ss
		852832 Y755_SYNY3 (6-196): 2.49e-87: 257: 55.73		THIO_SYNY3 (59-165): 8.35e-39: 129: 31.78
+	At
		1227668 BAS1B_ARATH (8-196): 2.34e-87: 259: 58.64		TRXX_ARATH (2-165): 2.67e-36: 125: 23.53
+	At
		1227667 BAS1A_ARATH (8-196): 3.63e-86: 256: 58.64		TRXX_ARATH (2-165): 2.67e-36: 125: 23.53
+	Os
		1150818 BAS1_ORYSJ (8-196): 3.16e-86: 256: 57.07		TRXX_ORYSJ (1-165): 1.48e-35: 123: 22.99
+	Sc
		611720 TSA1_YEAST (6-196): 3.71e-86: 254: 60.21		TRX2_YEAST (61-154): 7.37e-36: 122: 31.92
+	Sc
		606199 TSA1_YEAST (6-196): 3.71e-86: 254: 60.21		TRX1_YEAST (61-154): 2.56e-35: 120: 37.23
+	Ss
		852848 Y755_SYNY3 (6-196): 2.49e-87: 257: 55.73		THIO1_SYNY3 (65-151): 3.22e-34: 117: 31.03
+	Sc
		606220 TSA2_YEAST (6-196): 8.74e-82: 242: 59.16		TRX1_YEAST (61-154): 2.56e-35: 120: 37.23