Protein: TSL1
Trehalose synthase complex regulatory subunit TSL1 (Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 123 kDa subunit)

Gene: TSL1
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P38427

Gene Ontology (top 5):
GO:0003824 - catalytic activity
GO:0005737 - cytoplasm
GO:0005946 - alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
GO:0005992 - trehalose biosynthetic process
GO:0030234 - enzyme regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

799692

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

6

16

Small-scale

0.951

High

727671

TPS2
Trehalose-phosphatase

4

14

Small-scale

0.900

High

799659

TPS3
Trehalose synthase complex regulatory subunit TPS3

3

16

High-throughput

0.836

High

799677

TSL1
Trehalose synthase complex regulatory subunit TSL1

2

16

Small-scale

0.743

High

523794

HSP71
Heat shock protein SSA1

4

8

High-throughput

0.666

High

526567

HSP72
Heat shock protein SSA2

3

8

High-throughput

0.624

High

544702

SSB1
Ribosome-associated molecular chaperone SSB1

3

6

High-throughput

0.624

High

741483

HSP7F
Heat shock protein homolog SSE1

2

10

High-throughput

0.552

High

518006

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.536

High

799678

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

2

High-throughput

0.536

High

799686

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.533

High

450577

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.513

High

763223

PP2C1
Protein phosphatase 2C homolog 1

1

0

High-throughput

0.513

High

799691

UFD2
E4 ubiquitin-protein ligase UFD2

1

0

High-throughput

0.513

High

799698

HSP42
Heat shock protein 42

1

0

Small-scale

0.480

High

392654

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

723604

MLS1
Malate synthase 1

1

1

High-throughput

0.479

High

726982

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

739352

ZUO1
Zuotin

1

3

Small-scale

0.479

High

747826

SMY2
Protein SMY2

1

3

High-throughput

0.479

High

762904

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

3

High-throughput

0.479

High

782159

LAS1
Protein LAS1

1

1

Small-scale

0.479

High

795315

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

795709

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.479

High

799680

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

799689

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

670643

SIS1
Protein SIS1

1

6

High-throughput

0.470

High

585487

KCY
Uridylate kinase

1

0

High-throughput

0.458

High

799682

SBE22
Protein SBE22

1

0

High-throughput

0.458

High

453570

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

592220

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

675965

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

799695

HSP31
Glutathione-independent glyoxalase HSP31

1

1

High-throughput

0.445

High

679625

CDC48
Cell division control protein 48

1

3

High-throughput

0.437

High

706964

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

713223

SEC65
Signal recognition particle subunit SEC65

1

2

High-throughput

0.437

High

793592

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

2

High-throughput

0.437

High

794960

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

799679

MUP3
Low-affinity methionine permease

1

2

High-throughput

0.437

High

799681

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

3

High-throughput

0.437

High

799684

NSA2
Ribosome biogenesis protein NSA2

1

1

High-throughput

0.437

High

799688

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.437

High

799690

COPA
Coatomer subunit alpha

1

3

High-throughput

0.437

High

799693

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

High-throughput

0.437

High

799696

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.437

High

799697

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

1

Small-scale

0.437

High

799685

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

799683

NOC2
Nucleolar complex protein 2

1

0

High-throughput

0.279

Low

511184

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

538336

PYC1
Pyruvate carboxylase 1

1

0

High-throughput

0.249

Low

784307

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.249

Low

793035

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

High-throughput

0.249

Low

799687

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

799694

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025