HitPredict

Interactor 1: NTRK1 (P35739)
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (Slow nerve growth factor receptor) (p140-TrkA) (Trk-A)
Gene: NTRK1

Interactor 2: SH2B3 (P50745)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22028877
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 799 Rn			1 368
+	Hs
		384114 NTRK1_HUMAN (1-799): 0: 640: 85.73		LYN_HUMAN (8-357): 1.47e-65: 217: 14.83
+	Hs
		384184 NTRK1_HUMAN (1-799): 0: 640: 85.73		SRC_HUMAN (80-357): 4.01e-65: 217: 16.24
+	Rn
		728446 NTRK1_RAT (1-799): 0: 662: 100.00		SH2B1_RAT (21-357): 8.85e-46: 168: 29.97
+	Mm
		1112475 NTRK1_MOUSE (1-799): 0: 662: 96.25		SHC3_MOUSE (38-220): 1.48e-43: 158: 21.86
+	Hs
		384538 NTRK1_HUMAN (1-799): 0: 640: 85.73		VAV2_HUMAN (13-259): 3.67e-47: 173: 15.18
+	Rn
		728442 NTRK1_RAT (1-799): 0: 662: 100.00		GRB2_RAT (112-260): 6.87e-43: 150: 18.13
+	Hs
		145965 NTRK1_HUMAN (1-799): 0: 640: 85.73		SH2B2_HUMAN (75-252): 2.87e-45: 166: 43.26
+	Hs
		385257 NTRK1_HUMAN (1-799): 0: 640: 85.73		SHC3_HUMAN (28-221): 5.62e-45: 164: 22.68
+	Hs
		385574 NTRK1_HUMAN (1-799): 0: 640: 85.73		SH2B1_HUMAN (65-357): 4.64e-40: 152: 34.55
+	Hs
		384619 NTRK1_HUMAN (1-799): 0: 640: 85.73		GRB2_HUMAN (112-260): 6.87e-43: 150: 18.13
+	Rn
		728445 NTRK1_RAT (1-799): 0: 662: 100.00		SHC1_RAT (74-219): 6.48e-31: 124: 27.40
+	Mm
		957230 NTRK1_MOUSE (1-799): 0: 662: 96.25		SHC1_MOUSE (105-219): 1.54e-29: 121: 32.17
+	Hs
		384433 NTRK1_HUMAN (1-799): 0: 640: 85.73		MATK_HUMAN (98-199): 9.25e-33: 129: 30.39
+	Mm
		1112476 NTRK1_MOUSE (1-799): 0: 662: 96.25		PLCG1_MOUSE (106-259): 1.73e-22: 101: 15.58
+	Hs
		384331 NTRK1_HUMAN (1-799): 0: 640: 85.73		SHC1_HUMAN (74-219): 8.83e-30: 122: 27.40
+	Hs
		385029 NTRK1_HUMAN (1-799): 0: 640: 85.73		SHC4_HUMAN (95-219): 1.26e-23: 104: 27.91
+	Hs
		384239 NTRK1_HUMAN (1-799): 0: 640: 85.73		PLCG1_HUMAN (106-259): 1.36e-22: 101: 15.58
+	Hs
		385265 NTRK1_HUMAN (1-799): 0: 640: 85.73		P55G_HUMAN (105-224): 2.99e-18: 87.5: 25.41
+	Hs
		384316 NTRK1_HUMAN (1-799): 0: 640: 85.73		P85A_HUMAN (101-224): 1.97e-17: 85.6: 24.00
+	Hs
		562650 NTRK3_HUMAN (12-799): 0: 550: 47.36		PLCG2_HUMAN (6-343): 2.92e-46: 171: 18.49