HitPredict

Interactor 1: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Interactor 2: K1C40 (Q6A162)
Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)
Gene: KRT40

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.917

Property	Details
Experiments	25416956, 25910212, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, split luciferase complementation, two hybrid bait and prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 639 Hs			1 431
+	Hs
		280508 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53
+	Hs
		359290 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C14_HUMAN (87-400): 4.31e-146: 425: 53.82
+	Hs
		280507 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		KRT34_HUMAN (29-430): 8.36e-153: 440: 62.53
+	Hs
		409071 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KT33B_HUMAN (23-429): 5.43e-111: 333: 58.48
+	Hs
		408980 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C19_HUMAN (82-397): 4.55e-103: 313: 51.90
+	Hs
		409054 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C17_HUMAN (82-401): 2.06e-100: 307: 52.81
+	Hs
		408981 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C16_HUMAN (85-412): 2.56e-96: 298: 51.52
+	Hs
		409000 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C15_HUMAN (88-401): 4.65e-95: 295: 52.38
+	Hs
		49549 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		A1A4E9_HUMAN (80-411): 7.5e-95: 294: 50.75
+	Hs
		408990 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C13_HUMAN (80-411): 1.72e-94: 293: 50.75
+	Hs
		444534 K2C7_HUMAN (86-542): 4.82e-131: 395: 52.62		K1C17_HUMAN (82-401): 2.06e-100: 307: 52.81
+	Hs
		409184 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT35_HUMAN (2-427): 4.45e-87: 274: 59.35
+	Hs
		280770 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT36_HUMAN (7-407): 2.14e-84: 267: 63.34
+	Hs
		409072 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1H2_HUMAN (1-426): 1.69e-83: 265: 55.63
+	Hs
		409116 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1C40_HUMAN (1-431): 4.93e-84: 265: 100.00
+	Hs
		280943 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT38_HUMAN (1-430): 8.86e-77: 247: 49.77
+	Hs
		280845 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		KRT37_HUMAN (1-429): 1.93e-75: 243: 48.25
+	Hs
		409082 K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33		K1H1_HUMAN (48-425): 7.13e-75: 241: 63.23
+	Hs
		280768 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		KRT36_HUMAN (7-407): 2.14e-84: 267: 63.34
+	Hs
		280844 K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94		KRT37_HUMAN (1-429): 1.93e-75: 243: 48.25